Nlaz mutation

Species: Fruit fly (Taxid: 7227)
Factor: Nlaz
Manipulation: Loss-of-Function, Mutation

Absence of Nlaz, which is homologous to ApoD, results in a reduced lifespan in both sexes. Median lifespan is 30.8% and 22.5% lower in females and males, respectively. Maximum lifespan is reduced by 12% and 30% in females and males [21376794].

Median: -22.5 to -30.8
Maximum: -12 to -30

  • 21376794: Sex-dependent modulation of longevity by two Drosophila homologues of human Apolipoprotein D, GLaz and NLaz.

  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

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