Loco mutation

Species: Fruit fly (Taxid: 7227)
Factor: Loco
Manipulation: Loss-of-Function, Mutation

Reduced expression of Loco due to hetero-deficient results in a 17-20% longer mean lifespan for both male and females, besides the fact that the homozygous deficiency of loco is lethal. Several of these long-lived mutants are more resistant to stresses such as starvation, oxidation ad heat. Additional mutant have higher Manganese-containing superoxide dismutase (MnSOD) activity, increased fat content an diminished cAMP levels. Loco RGS domain is required for the regulation of longevity as deletion analysis suggest [21776417].

Mean: +17 to +20

  • 21776417: Loco signaling pathway in longevity.

  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

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