DNApol-gamma35 overexpression

Species: Fruit fly (Taxid: 7227)
Factor: DNApol-gamma35
Manipulation: Gain-of-Function, Overexpression

Overexpression of DNApol-gamma35 (DNA polymerase gamma) in the nervous system results in a decrease in the median lifespan ranging from 39% to 52% [17999718].

Mean: -39 to -52

  • 17999718: Over-expression of the catalytic core of mitochondrial DNA (mtDNA) polymerase in the nervous system of Drosophila melanogaster reduces median life span by inducing mtDNA depletion.

  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

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