Denigma

DNApol-gamma35 overexpression

Species: Fruit fly (Taxid: 7227)
Factor: DNApol-gamma35
Manipulation: Gain-of-Function, Overexpression
Effect:

Overexpression of DNApol-gamma35 (DNA polymerase gamma) in the nervous system results in a decrease in the median lifespan ranging from 39% to 52% [17999718].

Mean: -39 to -52

References:
  • 17999718: Over-expression of the catalytic core of mitochondrial DNA (mtDNA) polymerase in the nervous system of Drosophila melanogaster reduces median life span by inducing mtDNA depletion.


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

    • Edit / Update (Admin) | Delete

    Comment on This Data Unit