14-3-3epsilon mutation

Species: Fruit fly (Taxid: 7227)
Factor:
Manipulation: Loss-of-Function, Mutation
Effect:

Loss of 14-3-3ε results in increased stress-induced apoptosis, growth repression and extended lifespan of flies, in a foxo-dependent manner. Mean lifespan of males and females is increased by 25% and 49%, respectively. Increased 14-3-3ε expression also reverts foxo-induced growth defects. No effect of lifespan is observed when overexpressing 14-3-3ε in adipose tissue, indicating that endogenous foxo activity in this tissue is low under normal conditions [18665908].

Mean: +25 to +49

References:
  • 18665908: 14-3-3 Epsilon antagonizes FoxO to control growth, apoptosis and longevity in Drosophila.




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