Denigma

UCP2 overexpression

Species: Fruit fly (Taxid: 7227)
Factor: UCP2
Manipulation: Gain-of-Function, Overexpression
Effect:

Overexpression of human UCP2 in the fly nervous system extends lifespan by 10-30%. Ubiquitous overexpression is lethal [16054055].

Mean: +10 to +30

References:
  • 16054055: Targeted expression of the human uncoupling protein 2 (hUCP2) to adult neurons extends life span in the fly.


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

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