Denigma: Intervention

Fgf23 knockout

Species: House mouse (Taxid: 10090)
Factor: Fgf23
Manipulation: Loss-of-Function, Knockout, Mutation, Deletion
Effect:

Fgf23 knockouts have a short lifespan and display premature aging-like symptoms including kyphosis, muscle wasting, osteopenia, emphysema, uncoordinated movement, atherosclerosis, and atrophy of the intestinal villi, skin, thymus, and spleen [16436465].

Lack of Fgf23 activities results in extensive premature aging-like features and early mortality of Fgf-23(-/-) mice, while restoring the systemic effects of FGF-23 significantly ameliorates these phenotypes, with the resultant effect being improved growth, restored fertility, and significantly prolonged survival of double mutants [18729070].

References:

16436465: Premature aging-like phenotype in fibroblast growth factor 23 null mice is a vitamin D-mediated process.

18729070: Amelioration of the premature ageing-like features of Fgf-23 knockout mice by genetically restoring the systemic actions of FGF-23.

Aging Relevance Analysis/Source:

GenAge