Brca1 deletion

Species: House mouse (Taxid: 10090)
Factor: Brca1
Manipulation: Loss-of-Function, Mutation, Deletion

Deletion of Brca1 causes senescence in mutant embryos and cultured cells and tumorigenesis and signs of premature aging in adults [12533509]. Brca1 heterozygous seem to have shortened lifespan with 70% of tumor incidence. Lymphoma, but not ovarian and mammary gland tumors, occurs commonly in these animals. After a whole-body exposure to ionizing radiation, Brca1 heterozygous mice have a 3-5-fold higher incidence to ovarian tumors, but not lymphoma, when compared with Brca1(+/+) mice [17420720].

  • 17420720: Brca1 heterozygous mice have shortened life span and are prone to ovarian tumorigenesis with haploinsufficiency upon ionizing irradiation.
  • 12533509: Senescence, aging, and malignant transformation mediated by p53 in mice lacking the Brca1 full-length isoform.

  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

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