Atm knockout

Species: House mouse (Taxid: 10090)
Factor: Atm
Manipulation: Loss-of-Function, Knockout, Mutation
Effect:

Atm-deficient mice are viable, retarded in growth, infertile (male produce no mature sperm and female no gametes), display neurological dysfunction, and exhibit severe defects in T cell maturation while going on to develop thymomas [8917548; 8689683]. The majority of mutant mice rapidly develop thymic lymphomas and die before 4 months of age [8843194].

Cells of Atm(-/-) mice exhibit slow growth also in culture and premature senescence, telomeres are extensively shortened in multiple tissues [8689683].

Mice mutant for Atm and Terc display progressive multi-organ system compromise and features of accelerated aging [12540856].


References:
  • 8843194: Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma.
  • 8917548: Pleiotropic defects in ataxia-telangiectasia protein-deficient mice.
  • 12540856: Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing.
  • 8689683: Atm-deficient mice: a paradigm of ataxia telangiectasia.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR



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