Bub1b overexpression

Species: House mouse (Taxid: 10090)
Factor: Bub1b
Manipulation: Gain-of-Function, Overexpression
Effect:

Sustained high-level expression of BubR1 preserves genomic integrity and reduces tumorgenesis (even in the presence of genetic alterations that strongly promote aneuplodization and cancer, such as oncogenic Ras) and extends the lifespan and delays age-related deterioriation and aneuploidy in several tissues [23242215].

BubR1 overabundance exerts its protective effect by correcting mitotic checkpoints defects [23242215].

BubB1 overexpression extends maximum lifespan by 20 - 41% compared to GFP-carrying control transgenic mice [23242215].

Maximum: +20 to +41.3

References:
  • 23242215: Increased expression of BubR1 protects against aneuploidy and cancer and extends healthy lifespan.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR
  • Comparisons:
  • T23 vs. WT : 24.7(max)
  • T23 vs. T-GFP : 41.3(max)
  • T23 vs. WT : -5.1(max)
  • T23 vs. T-GFP : 24.9(max)
  • T23 vs. WT : -15.4(max)
  • T23 vs. T-GFP : 20.0(max)



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