Metformin treatment

Species: Nematode (Taxid: 6239)
Factor: Met
Manipulation: Diet Intervention, Drug treatment
Effect:

Metformin treatment extends healthspan, slows lipofuscin accumulation, extends mean lifespan and prolongs healthful locomotory ability in a dose-dependent manner as well as reduces fecundity. AMPK and its activating kinase LKB1 are essential for these health benefits. Oxidative stress-responsive transcription factor SKN-1/Nrf2 is essential for metformin-confered healthspan too as it must be expressed in both neurons and intestines [20090912].


References:
  • 20090912: Metformin induces a dietary restriction-like state and the oxidative stress response to extend C. elegans Healthspan via AMPK, LKB1, and SKN-1.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR



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