Denigma

wrn-1 mutation

Species: Nematode (Taxid: 6239)
Factor: wrn-1
Manipulation: Loss-of-Function, Mutation
Effect:

A nonfunctional wrn-1 DNA helicase decreases the lifespan [23075628].

The expression of miR-124 in whole wrn-1 mutant worms is significantly reduced [23075628].

Supplementation of vitamin C normalizes the median lifespan of wnr-1 and mir-124 mutants [23075628].


References:
  • 23075628: Down regulation of miR-124 in both Werner syndrome DNA helicase mutant mice and mutant Caenorhabditis elegans wrn-1 reveals the importance of this microRNA in accelerated aging.


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

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