mir-239 mutation

Species: Nematode (Taxid: 6239)
Factor: mir-239
Manipulation: Loss-of-Function, Mutation
Effect:

Mutating mir-239 increases mean and maximum lifespan by 12 and 36%, respectively. Lifespan extension by mir-239 loss-of-function requires daf-16 [21129974].

Mean: +11.8
Maximum: +36.0

References:
  • 21129974: MicroRNAs both promote and antagonize longevity in C. elegans.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR
  • Comparisons:
  • mir-239(nDf62) vs. control ( 20°C ) : 11.8(mean) 36(max)
  • mir-239(nDf62) vs. wild-type ( 20°C ) : 11.1(mean) 17.4(max)
  • mir-239(nDf62) RNAi vs. wild-type ( 20°C ) : -27.8(mean) -21.7(max)
  • mir-239(nDf62) RNAi vs. wild-type ( 20°C ) : 44.4(mean) 43.5(max)



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