Denigma

mir-71 overexpression

Species: Nematode (Taxid: 6239)
Factor: mir-71
Manipulation: Gain-of-Function, Overexpression
Effect:

Gain-of-function of mir-71 increases lifespan [21129974]. Extra copies of mir-71 extend the lifespan with an increase in lifespan by 15 - 25% [22482727],

Mean: +15 to +25

References:
  • 21129974: MicroRNAs both promote and antagonize longevity in C. elegans.
  • 22482727: The C. elegans microRNA mir-71 acts in neurons to promote germline-mediated longevity through regulation of DAF-16/FOXO.


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

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