Denigma

Dcr-2 mutation

Species: Fruit fly (Taxid: 7227)
Factor: Dcr-2
Manipulation: Loss-of-Function, Mutation
Effect:

Median lifespan of homozyogous and transheterozyogous Dcr-2 mutants is reduced by 18-36% in males and by 27-36% in females. Dcr-2 loss changes the expression of mostly metabolic genes implicated in stress resistance and aging. Dcr-2 mutants are hypersensitive to oxidative, endoplasmic reticulum, starvation and cold stress as well as abnormal lipid and carbohydrate metabolism [21889502].

Mean: -18 to -36

References:
  • 21889502: The endogenous siRNA pathway in Drosophila impacts stress resistance and lifespan by regulating metabolic homeostasis.


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

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