Denigma

VPH2 overexpression

Species: Budding yeast (Taxid: 4932)
Factor: VPH2
Manipulation: Gain-of-Function, Overexpression
Effect:

Overexpression of VPH2 increases the levels of assembled V-ATPase at the vacuolar membrane, increases vacuolar acidity and suppresses age-induced mitochondrial dysfunction of aged cells (17 or 18 cell divisions) which requires the V-ATPase activity. VPH2 overexpression significantly increases mean, median and maximum replicative lifespan by 23, 25 and 34%, respectively [23172144].

Mean: +23.1
Median: +25.0
Maximum: +34.0

References:
  • 23172144: An early age increase in vacuolar pH limits mitochondrial function and lifespan in yeast.


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR
    • Comparisons:
  • VPH2(OE) vs. WT : 23.1(mean) 25(median) 34(max) 0.0054(p-value)

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