Denigma

VMA1 overexpression

Species: Budding yeast (Taxid: 4932)
Factor: VMA1
Manipulation: Gain-of-Function, Overexpression
Effect:

Overexpression of VMA1 increases vacuolar acidity and suppresses age-induced mitochondrial dysfunction of aged cells (17 or 18 cell divisions) which requires the V-ATPase activity. VMA1 overexpression significantly increases mean, median and maximum lifespan by 39 - 45%, 39 - 48% and 50 - 60%, respectively. DR (0.5% glucose restriction) does not further increase the lifespan of VMA1 overexpression strain [23172144].

Mean: +39.3 to +44.8
Median: +39.3 to +48.3
Maximum: +50.0 to +60.0

References:
  • 23172144: An early age increase in vacuolar pH limits mitochondrial function and lifespan in yeast.


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR
    • Comparisons:
  • VMA1(OE) vs. WT : 39.3(mean) 39.3(median) 60(max) 0.0002(p-value)
  • VMA1(OE) vs. WT : 44.8(mean) 48.3(median) 50(max) <0.0001(p-value)
  • VMA1(OE) DR vs. WT : 37.9(mean) 37.9(median) 28(max) 0.076(p-value)

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