pash-1 mutation

Species: Nematode (Taxid: 6239)
Factor: pash-1
Manipulation: Loss-of-Function, Mutation
Effect:

pash-1 mutants have a decreased lifespan and display phenotypic and molecular signs of advantaged age earlier.

pash-1(mj100) temperature sensitive loss-of-function mutation decreases (at the permissive temperature) mean and maximum lifespan by 31 and 71%, respectively. At the restrictive temperature pash-1 mutants are slightly short-lived with a mean and maximum lifespan reduction by 13 and 54%. Lifespan of pash-1 mutants is reduced by a 24h upshift to 25 degree Celsius at the young adult stage with (36 and 78% reduction mean and maximum lifespan, respectively) [23097426].

The rescue of pash-1 expression all tissues restored almost normal lifespan. Rescue specifically in hypodermis, pharynx muscle, gut had no effect on lifespan. Rescue in body wall muscle marginal extended the lifespan, while rescue specifically in the neurons significantly restored mean but not maximum lifespan. Lifespan was also restored by combined rescue in hypodermis and muscle [23097426].

Mean: -31
Maximum: -71

References:
  • 23097426: Post-developmental microRNA expression is required for normal physiology, and regulates aging in parallel to insulin/IGF-1 signaling in C. elegans.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR



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