DDS treatment

Species: Nematode (Taxid: 6239)
Factor: DDS
Manipulation: Diet Intervention, Drug treatment
Effect:

Treatment with DDS either for the entire lifetime or only during the adult period after the L4 stage extends significantly increases mean and maximum lifespan [20974969]

DDS causes the delay of aging, reduces lipofuscin accumulation and decreases the level of a mitochondrial complex as well as lowers oxygen consumption and enhances oxidative stress resistance [20974969].

DDS-conferred lifespan extension is independent of daf-16 and DR (eat-2 mutants) [20974969].


References:
  • 20974969: DDS, 4,4'-diaminodiphenylsulfone, extends organismic lifespan.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR



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