CG13890 overexpression

Species: Fruit fly (Taxid: 7227)
Factor: CG13890
Manipulation: Gain-of-Function, Overexpression

Overexpression of CG13890 (DCI) throughout the whole body increases mean and median lifespan by 35 and 31%, but decreases maximum lifespan by 6%, increases stress resistant (to paraquat and starvation), consistently reduces the mortality rate across adult ages and reduces the lifespan extension of DR by 15% [22997544].

CG6783 overexpression increases the dFOXO nuclear localization in the fat-body. mRNA levels of dFOXO target genes l(2)efl and 4E-BP in the adult whole bodies increases in response to overexpression of CG6783 [22997544].

Mean: +35
Median: +31
Maximum: +6

  • 22997544: Overexpression of Fatty-Acid-β-Oxidation-Related Genes Extends the Lifespan of Drosophila melanogaster.

  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR
  • Comparisons:
  • EPCG13890/+ vs. da/+ ( male ) : 23.1(mean) -12.5(max)
  • da>EPCG13890 vs. da/+ ( male ) : 34.6(mean) 31.3(median) -6.3(max)

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