Denigma

dj-1beta mutation

Species: Fruit fly (Taxid: 7227)
Factor: dj-1beta
Manipulation: Loss-of-Function, Mutation
Effect:

Loss of function mutation in dj-1beta shortens maximum lifespan by 40% and results in increased sensitivity to oxidative stress and motor impairments [17651920].

Maximum: -40

References:
  • 17651920: Drosophila DJ-1 mutants are sensitive to oxidative stress and show reduced lifespan and motor deficits.


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

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