AFG3 deletion

Species: Budding yeast (Taxid: 4932)
Factor: AFG3
Manipulation: Loss-of-Function, Knockout, Mutation
Effect:

Deletion of the mitochondrial AAA protease AFG3 increases replicative lifespan by 20% in the alpha and a strains [18340043], but decreases chronological lifespan by 37 - 51% in diploid cells [21447998]. AFG3 deletion changes mean, median and maximum lifespan by 15 to 26% 17 to 30% and -25 to +58%, respectively.

AFG3 deletion leads to reduced cytoplasmic mRNA translation and its lifespan extension is independent of Sir2 and Hac1, but requires Gcn4. AFG3 deletion further extends the lifespan of cell deficient in both SIR2 and FOB1, but fails to extend the lifespan of dietary restricted cells or cells lacking GCN4. Gcn4 protein levels are increased in afg3 mutants. The deletion of AFG3 fails to extend the replicative lifespan in the W303AR strain. AFG3 deletion does deletion extend the replicative lifespan at 15°C.

Mean: -51 to +20

References:

18340043: Quantitative evidence for conserved longevity pathways between divergent eukaryotic species.

21447998: A genomic analysis of chronological longevity factors in budding yeast.

Aging Relevance Analysis/Source:

GenAge

GenDR

Comparisons:

afg3 vs. wild-type ( 30°C ) : 25.6(mean) 26.3(median) 57.9(max)

afg3 vs. wild-type ( 30°C ) : 25.9(mean) 30(median) 39.5(max)

afg3 vs. wild-type ( 30°C ) : 22.2(mean) 26.3(median) 36.4(max)

afg3 vs. wild-type ( 30°C ) : 15.0(mean) 19.2(median) -24.6(max) 0.0525(p-value)

afg3 vs. wild-type ( 15°C ) : 5.4(mean) 22.5(max) 0.721(p-value)

afg3 vs. wild-type ( 30°C ) : 22.4(mean) 16.7(median) 47.4(max)

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