Fgf21 overexpression

Species: House mouse (Taxid: 10090)
Factor:
Manipulation: Gain-of-Function, Overexpression
Effect:

Overexpression of Fgf-21 increases the mean lifespan by 30% for male mice and 39% for female mice [23066506].

Mice overproducing Fgf21 are lean throughout their lives and remain lean even while eating slightly more than wild-type mice. Fgf21 overproducers tend to be smaller than wild-type mice and female mice were infertile. Although Fgf21 overproducers have significantly lower bone density than wild-type, Fgf21-abundant mice exhibit no ill effects from the reduced bone density and remain active into old age without any broken bones [23066506].

Mean: +30 to +39



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