Atg8a mutation

Species: Fruit fly (Taxid: 7227)
Factor: Atg8a
Manipulation: Loss-of-Function, Mutation
Effect:

Mutations in Atg8a results in reduced lifespan and increased sensitivity to oxidative stress [18059160].

Atg8a mutation reduces the maximum lifespan by 25% under starvation conditions [17617737].

Loss-of-function mutation in atg8a reduces mean lifespan by 11 - 25% and maximum lifespan by 3 - 22% [17435236].

Mean: -11 to -25
Maximum: -3 to -25

References:
  • 18059160: Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila.
  • 17435236: Genetic modifiers of the Drosophila blue cheese gene link defects in lysosomal transport with decreased life span and altered ubiquitinated-protein profiles.
  • 17617737: Linking lysosomal trafficking defects with changes in aging and stress response in Drosophila.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR
  • Comparisons:
  • atg8aep362 vs. Canton-S ( 25°C male ) : -10.6(mean) -2.9(max) 0.004(p-value)
  • atg8a vs. white1118 ( 29°C male ) : -24.6(mean) -22.4(max) <0.0001(p-value)



  • Edit / Update (Admin) | Delete

    Comment on This Data Unit