aak-2 mutation

Species: Nematode (Taxid: 6239)
Factor: aak-2
Manipulation: Loss-of-Function, Knockout, Mutation
Effect:

aak-2(ok524) knockout mutants have a 12% and 18% shorter mean and maximum lifespan, respectively as well as faster age-dependent accumulation of a lipofuscin-like fluorescent pigment in the intestine [15574588]. aak-2 mutation suppresses lifespan extension and delay of the decline in locomotor activity resulting from sDR [17900900]. aak-2 mutation cancels out the lifespan extension effect of sDR and PD, regardless of the concentration of bacteria or peptones. bDR significantly extends lifespan of aak-2 mutants, but to lesser extent than that of wild-type. eat-2 mutation extends the lifespan of aak-2 mutants to the same extent than that of wild-type. Resveratrol does not increase lifespan of aak-2 mutants [19239417]. daf-2(m577);aak-2(ok524) double mutant has a lifespan that is indistinguishable from those of aak-2(ok524) single mutant [15574588].

Mean: -12
Maximum: -18

References:
  • 15574588: The AMP-activated protein kinase AAK-2 links energy levels and insulin-like signals to lifespan in C. elegans.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR



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