NTH1 deletion

Species: Budding yeast (Taxid: 4932)
Factor: NTH1
Manipulation: Loss-of-Function, Knockout, Mutation, Deletion
Effect:

Deletion of NTH1 decreases mean replicative lifespan by 15% in the a strain [19030232] and mean chronological lifespan by 30% (at 30 degree Celsus in BY4742) [22783207].

Mutant NTH1 cells have reduced oxidative carbonylation of cellular proteins throughout lifespan. NTH1 mutant cells have elevated trehalose concentration and reduced oxidative carbonylation of cellular proteins before they enter the non-proliferative stationary growth phase which remained high during the stationary phase [22783207].

Mean: -30

Aging Relevance Analysis/Source:
  • GenAge
  • GenDR



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