RNA interference of drr-2 extends lifespan [15998808]. drr-2 RNAi extends lifespan of wild-type by 10-16%, but fails to significantly extend lifespan of daf-2 mutants or eat-2 mutants. drr-2 RNAi keeps a normal, well-fed appearance and normal reproduction. drr-2 mRNA expression is 2-fold reduced in eat-2 mutants [16103914]. drr-2 RNAi significantly reduces paralysis in Q35YFP transgenic animals [18331616]. drr-2 overexpression suppresses lifespan extension by eat-2 mutation and solid plate-based DR [20456299].
GenAge
GenDR
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