pha-4 RNAi

Species: Nematode (Taxid: 6239)
Factor: pha-4
Manipulation: Loss-of-Function, Knockdown, RNA Interference
Effect:

RNAi of pha-4 completely cancels out the lifespan extension of eat-2 mutation. Therefore, loss of pha-4 completely blocks the response to varying food concentration. sDR extends lifespan pha-4 RNAi knockdown, but not daf-16 RNAi [19239417]. RNAi of pha-4 decreases lifespan of wild-type worms, but not of daf-2 mutants or of animals with defective electron transport chains.


Aging Relevance Analysis/Source:
  • GenAge
  • GenDR



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