wwp-1 RNAi

Species: Nematode (Taxid: 6239)
Factor: wwp-1
Manipulation: Gain-of-Function, Loss-of-Function, Knockout
Effect:

RNA interference of wwp-1 decreases median lifespan by 9% in wild-type animals and 24% in daf-2 mutants [18006689]. Loss of wwp-1 function by RNAi reduces lifespan at 25 degree Celsius, but not 20 degree Celsius. Reduced levels of wwp-1 completely suppress the extended longevity of eat-2 mutants. wwp-1 RNAi does not suppress the extended lifespan of isp-1 mutants and has only minor suppressive effects on lifespan of another mitochondrial mutant, clk-1, and in cyc-1 RNAi treated worms. RNAi depletion of wwp-1 has no effect on long lifespan of daf-2 mutants [19553937].

Median: -9

Aging Relevance Analysis/Source:
  • GenAge
  • GenDR



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