Denigma

ire-1 mutation

Species: Nematode (Taxid: 6239)
Factor: ire-1
Manipulation: Loss-of-Function, Knockout, Mutation
Effect:

ire-1 mutation reduces slightly the lifespan under AL, but reduces significantly the lifespan extension by DR. ire-1 mutant has a significantly reduced slope in mean lifespan versus food concentrations relative to wild-type. ire-1 mutation fully suppresses lifespan extension by hif-1 mutation under AL and DR conditions [19461873].


Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

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