Denigma: Intervention

FKH1 FKH2 deletion

Species: Budding yeast (Taxid: 4932)
Factor: FKH1 FKH2
Manipulation: Loss-of-Function, Knockdown, Mutation, Deletion
Effect:

Deletion of FKH1 or FKH2 has no effect on neither replicative, nor chronological lifespan [18225956]. Deletion of both FKH1 and FKH2 reduces mean chronological lifespan by 50% and abrogates lifespan extension and increased stress resistance conferred from water starvation (extreme DR). Modest increase in FKH1 or FKH2 expression results in a slight increased chronological and replicative lifespan as well as stress resistance [22438832].

Aging Relevance Analysis/Source:

GenAge