| aak-2 | AMP-Activated Kinase 2 | AAK-2 could be a sensor that couples energy levels and insulin-like signals to lifespan. aak-2(ok524) knockout mutants have a 12% and 18% shorter mean and maximum lifespan, respectively as well as faster age-dependent accumulation of a lipofuscin-like fluorescent pigment in the intestine [15574588]. sDR increases AMP:ATP ratio. aak-2 mutation suppresses lifespan extension and delay of the decline in locomotor activity resulting from sDR. A constitutive active mutation of aak-2 is sufficient to cause increase stress resistance as well as to significantly extend lifespan. Both increased stress resistance and extended lifespan is reverted in daf-16 knockdown by RNAi. sod-3 mRNA is increased by constitutive active form of aak-2 and decreased by aak-2 mutation. The increase in sod-3 mRNA is dependent on expression of DAF-16. Worm and human AMPK phosphorylate DAF-16 (greatly enhanced by presence of AMP) at least in six residues (T166, S202, S314, S321, T463 and S466) [17900900]. aak-2 mutation cancels out the lifespan extension effect of sDR and PD, regardless of the concentration of bacteria or peptones. bDR significantly extends lifespan of aak-2 mutants, but to lesser extent than that of wild-type. eat-2 mutation extends the lifespan of aak-2 mutants to the same extent than that of wild-type. Resveratrol does not increase lifespan of aak-2 mutants [19239417]. daf-2(m577);aak-2(ok524) double mutant has a lifespan that is indistinguishable from those of aak-2(ok524) single mutant. Transgenic animals with a higher aak-2 gene dose live on average 13% longer with a maximum lifespan extension on up to 25% [15574588]. | Nematode |
| aat-8 | Amino Acid Transporter 8 | RNA interference of aat-8 increases mean lifespan by 30% [17608836]. | Nematode |
| abu-11 | Activated in Blocked Unfolded protein response 11 | Overexpression of abu-11 extends mean lifespan by 9% to 28% [16256736]. | Nematode |
| acl-11 | ACyLtransferase-like 11 | RNA interference of acl-11 leads to lifespan extension [12447374]. | Nematode |
| aco-2 | ACOnitase | RNA interference of aco-2 leads to lifespan extension [15998808]. | Nematode |
| age-1 | AGEing alteration 1 | Recessive knockout mutants of age-1 have a 40-65% increase in mean lifespan and a 65-110% increase in maximum lifespan [8608934; 8700226]. age-1(mg44) zygotic null mutants have a mean (99%) and maximum (117%) lifespan extension [18828672]. Even in axenic culture lifespan of age-1 is extended up to 100%. age-1 mutation significantly extends lifespan under AL, but only slightly under sDR [16720740].
RNAi against age-1 extends lifespan by 30% [8700226; 8608934]. age-1 RNAi increases mean and maximum lifespan by 36-46% and 48-50% [12447374]. RNAi against age-1 increases mean lifespan by 83% [18828672].
age-1 mutants are dauer constitutive [8056303] and display lower brood size as well as increased embryonic lethality [9504918]. Additionally, age-1 mutants have elevated levels of superoxidase dismutase and catalase activities [8389142]. age-1 RNAi and mutation extend lifespan by 30% and 100%, respectively [8700226; 8608934]. | Nematode |
| ain-1 | ALG-1 INteracting protein 1 | RNA interference of ain-1 decreases median lifespan by 10% in wild type animals, 20% in a daf-2 background and 44% in daf-2/daf-16 double mutants [18006689]. | Nematode |
| akt-1 | AKT kinase family 1 | RNA interference of akt-1 leads to lifespan extension [15998808]. | Nematode |
| alg-2 | Argonaute (plant)-Like Gene 2 | RNA interference of alg-2 decreases median lifespan by 24% in wild type animals and 50% in a daf-2 background [18006689]. | Nematode |
| amt-2 | AMmonium Transporter homolog 2 | RNA interference of amt-2 increases mean lifespan by 20% [17608836]. | Nematode |
| arl-8 | ARF-Like 8 | RNA interference of arl-8 decreases median lifespan by 35% in a daf-2 background and 9% in daf-2/daf-16 double mutants [18006689]. | Nematode |
| arx-4 | ARp2/3 compleX component 4 | RNA interference of arx-4 decreases median lifespan by 61% in a daf-2 background and 51% in daf-2/daf-16 double mutants [18006689]. | Nematode |
| asb-2 | ATP Synthase B homolog 2 | RNA interference of abs-2 leads to lifespan extension [16103914]. | Nematode |
| asg-1 | ATP Synthase G homolog 1 | RNA interference of asg-1 leads to lifespan extension [15998808]. | Nematode |
| asg-2 | ATP synthase subunit 2 | Knockout mutations in asg-2 result in developmental arrest and increased lifespan [11410594]. | Nematode |
| asm-3 | Acid SphingoMyelinase 3 | RNA interference of asm-3 increases mean lifespan by 50% [17608836]. | Nematode |
| atg-7 | AuTophaGy (yeast Atg homolog) 7 | RNA interference against atg-7 shortens mean lifespan by 23% and maximum lifespan by 30% in a eat-2 mutant background but not in wild-type animals. Thus, atg7 RNAi does not affect lifespan of wild-type, but totally cancels out the lifespan extension effect of eat-2 mutation [17912023]. | Nematode |
| atp-2 | ATP synthase F1 subunit gamma 2 | RNA interference of atp-2 results in extended lifespan [12471266]. atp-2 RNAi significantly extends mean lifespan by 14% [11410594]. | Nematode |
| atp-3 | ATP synthase subunit | RNA interference against atp-3 results in lifespan extension [16103914]. atp-3 RNAi increases lifespan by 46% (mean by 33 and maximum by 70%). RNAi of atp-3 during larval stage is necessary and sufficient for lifespan prologation, while atp-3 RNAi only during the adulthood fails the extend lifespan. atp-3 RNAi results in reduced pharageal pumping, defection and motility as well as ATP levels and body size [12471266]. | Nematode |
| atp-4 | ATP synthase subunit 4 | RNA interference of atp-4 results in lifespan extension [16103914]. | Nematode |
| atp-5 | ATP synthase subunit 5 | RNA interference of atp-5 results extended lifespan [16103914]. | Nematode |
| mrpl-47 | Mitochondrial Ribosomal Protein, Large | RNAi against mrpl-47 extends mean and maximum lifespan by 18% and 50%, respectively [12447374]. This lifespan extension is not suppressed by daf-16 mutation (mgDF74). mrpl-47 knockdown results in lower ATP content and oxygen consumption [12447374]. | Nematode |
| mboa-1 | Membrane Bound O-Acyl transferase, MBOAT 1 | RNA interference of mboa-1 decreases median lifespan by 16% in wild type animals, 28% in a daf-2 background and 12% in daf-2/daf-16 double mutants [18006689]. | Nematode |
| B0491.5 | — | RNA interference of B0491.5 in adulthood results in a 16% increase in mean lifespan [17521386]. | Nematode |
| B0511.6 | — | RNA interference of B0511.6 in adulthood extended mean lifespan by 50% [17411345]. | Nematode |
