Factors

We need to know every factor which determines lifespan.

Lifespan factors often but not always originate from defined genetic elements. They are not just genes, by definition they can be anything for which a Classifications schema can be build for that is related to the regulation of lifespan, such entities may include Single-Nucleotide Polymorphism, transcript variants, proteins and their complexes, compounds (i.e. small molecules like metabolites and drugs), etc. A factor should be based on a defined molecular entity or genomic position and been classified. It shall be highly flexible and scalable Concept.

While individual lifespan factors within each species or precise defined molecular entities will be captured within the Lifespan App, Data Entries of the Data App may summarize for instance the relevance of each factor class (e.g. homologous group; chemical derivate of related structure and properties, etc.) as well as draw overall conclusions. o

prometheus--2.jpg

  • Types: + -
  • symbol name observation species
    GCN4 Transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels Deletion of GCN4 increases the replicative lifespan by 10% in the alpha strain [19030232]. GCN4 deletion decreases the lifespan in the alpha and a strain [20657825]. The chronological lifespan of GCN4 deletion is strongly decreased in the a strain [20421943]. Budding yeast
    MIR1 Deletion of MIR1 increases replicative lifespan by 25% in the alpha strain [18340043] and mean chronological lifespan by 43 - 100% (43, 49, 59, 73, 69, 100) in diploid cells [21447998]. Budding yeast
    • 2 factors
    Factors are an extension of GenAge and GenDR.

    Comment on This Data Unit