| mtDNA | — | — | — |
| CYBA | — | — | Human |
| CDKN2B | — | — | Human |
| RAGE | — | — | Human |
| RS29_RAT | 40S ribosomal protein S29 | RS29_RAT is transcriptional upregulated in the cerebral cortex at the age 28 months under different longevity conditions such as under dietary restriction (DR) as well as in feeding switch regimens that result in extended lifespan, like early age switch to DR as well as the reverse switch under the influence of the DR-mimetic α-lipoic acid (i.e. DR switched to ad libitum+ lipoic acid) [Shona et al. 2013]. | Norway rat |
| SLC6A4 | solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 | SLC6A4 was found to be associated with longevity [15621215]. | Human |
| TAS2R16 | taste receptor, type 2, member 16 | TAS2R16 was found to be associated with longevity [23133589]. | Human |
| HSPA1A | heat shock 70kDa protein 1A | (A/C)-110 polymorphism in the HSPA1A gene was examined in 591 subjects (263 males and 328 females; age range 18-109 years; 36 male and 84 female centenarians). A significant age-related decrease of the frequency of allele (A)-110 was observed in females, while no difference was observed in the males [14501185].HSPA1A was found to be associated with longevity [16804002]. HSPA1A was found to be associated with longevity [14501185]. HSPA1A was found to be associated with longevity [16804002]. HSPA1A was found to be associated with longevity [20388090]. HSPA1A was found to be associated with longevity [20388090]. | Human |
| 16S rRNA | — | 16S rRNA was found to be associated with longevity [10996007]. | Human |
| MLH1 | mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli) | 3 SNPs in the coding region of MLH1 were analyzed in 85 Korean centenarians and in 106 Korean controls. The CAT haplotype (C670, A676 and T1172) frequency was significantly higher in the centenarians than in the controls [16474933]. MLH1 was found to be associated with longevity [22406557]. | Human |
| MTR | 5-methyltetrahydrofolate-homocysteine methyltransferase | 329 healthy individuals were examined for 2576A-->G (D919G) polymorphism in the MTR gene. Prevalence of the G-allele was significantly higher in the older than in the younger individuals. Separate analysis of female and male subjects revealed that the influence of the MTR genotype on male subjects became relevant at a younger age as opposed to female subjects suggesting a gender-dependent effect [16142417]. | Human |
| 3p22-24 region | — | 3p22-24 region was found to be associated with longevity [22506048]. | Human |
| 3p24-22 | — | 3p24-22 was found to be associated with longevity [20824210]. | Human |
| TGFB1 | transforming growth factor, beta 1 | 4 SNPs (-800 G/A, -509 C/T, +869 T/C and +915 G/C) in the TGFB1 gene were analysed in 419 subjects from Northern and Central Italy, including 172 centenarians and 247 younger controls. Significant differences were found at the +915 site as far as the C allele and GC genotype were concerned, both of them being lower in centenarians than in young controls, but none of the other tested genetic variants was significantly different between centenarians and controls. Moreover, a particular haplotype combination (G -800/C -509/C 869/C 915) was notably lower in centenarians than in younger individuals [15569360].TGFB1 was found to be associated with longevity [21299522]. TGFB1 was found to be associated with longevity [21299522]. TGFB1 was found to be associated with longevity [15569360]. | Human |
| INSR | insulin receptor | 5 intronic and 1 exonic polymorphisms in the INSR gene were examined in 122 semisupercentenarians (older than 105, 107 female, 15 male, mean age 106.8 years) and 122 healthy younger controls (105 female, 17 male, mean age 33.33). One haplotype, which was comprised of 2 intronic SNPs in linkage disequilibrium, was more frequent in semisupercentenarians than in younger controls [15582274].INSR was found to be associated with longevity [15582274]. INSR was not found to be associated with longevity [15582274]. INSR was not found to be associated with longevity [19489743]. | Human |
| 5HTT | solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 | 5HTT was found to be associated with longevity [16095668]. | Human |
| 6q25-27 region | — | 6q25-27 region was found to be associated with longevity [22773346]. | Human |
| HMOX1 | heme oxygenase (decycling) 1 | A (GT)n repeat polymorphism in the promoter region of the human HO-1 gene was examined in younger (60 years, 59 male and 45 female) and older (60-75 years, 95 male and 106 female) subjects. The proportion of allelic frequencies in class L with a large size of (GT)n repeat, as well as the genotypic frequencies in group I with class L alleles, was significantly lower in the oldest male subjects than in the younger males. In contrast, in the oldest female subjects this was not observed [12566526].HMOX1 was found to be associated with longevity [12566526]. | Human |
| YTHDF2 | YTH domain family, member 2 | A locus associated with human longevity corresponds to (TG)n microsatellite is located in the YTHDF2 gene. 412 participants of different ages, including 137 centenarians, were genotyped. The increased homozygosity in centenarians at this locus was confirmed, and observed a concomitantly increased frequency of the most frequent allele and the corresponding homozygous genotype. The same genotype was associated with increased YTHDF2 messenger RNA levels in immortalized lymphocytes. [16799135].YTHDF2 was found to be associated with longevity [16799135]. | Human |
| TP53 | tumor protein p53 | A naturally occuring allele with decreased p53 activity has been assoicated with extended survival [15732191].TP53 was found to be associated with longevity [23125046]. TP53 was found to be associated with longevity [18256523]. TP53 was found to be associated with longevity [15621215]. TP53 was found to be associated with longevity [18256523]. TP53 was not found to be associated with longevity [15195682]. TP53 was not found to be associated with longevity [15621215]. | Human |
| APOC1 | apolipoprotein C-I | A polymorphism in the APOC1 gene is significantly associated with longevity [21740922].APOC1 was found to be associated with longevity [21740922].APOC1 was found to be associated with longevity [21740922]. APOC1 was found to be associated with longevity [9105559]. | Human |
| APOB | apolipoprotein B (including Ag(x) antigen) | A sample of 143 centenarians and a control sample of 158 individuals were examined for polymorphism in APOB restriction fragment length (RFLP) (XbaI2488 and EcoRI4154) and variable number of tandem repeat (VNTR) (3'APOB-VNTR) polymorphisms. Neither the XbaI-RFLP nor the EcoRI-RFLP was able to discriminate between centenarians and controls, while the 3'APOB-VNTR multiallelic system revealed significant differences between the samples: the frequency of alleles with fewer than 35 repeats was lower in centenarians than in controls [9050915].apoB was found to be associated with longevity [17393087].APOB was found to be associated with longevity [15028112]. APOB was found to be associated with longevity [17393087]. APOB was not found to be associated with longevity [17393087]. APOB was found to be associated with longevity [9050915]. APOB was not found to be associated with longevity [11592926]. APOB was not found to be associated with longevity [8018664]. APOB was not found to be associated with longevity [9050915]. | Human |
| IGF2 | insulin-like growth factor 2 (somatomedin A) | A/G ApaI site SNP in the IGF2 gene was examined in 224 older (75 years) Jewish Jerusalem residents of Ashkenazi ethnicity (150 males and 74 females) and a group of 441 younger subjects (22 years). An increase in the A allele was observed in older Ashkenazi females and a highly significant increase was observed in the AA genotype in these subjects [15621215].IGF2 was found to be associated with longevity [19367319]. IGF2 was not found to be associated with longevity [19367319]. IGF2 was found to be associated with longevity [17989723]. IGF2 was found to be associated with longevity [15621215]. | Human |
| AAT | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | AAT was found to be associated with longevity [17048073]. AAT was found to be associated with longevity [17048073]. | Human |
| Abca2 | ATP-binding cassette sub-family A member 2 | Abca2 is transcriptional downregulated in the cerebral cortex at the age 28 months under different longevity conditions such as under dietary restriction (DR) as well as in feeding switch regimens that result in extended lifespan, like early age switch to DR as well as the reverse switch under the influence of the DR-mimetic α-lipoic acid (i.e. DR switched to ad libitum+ lipoic acid) [Shona et al. 2013]. | Norway rat |
