Denigma

Factors

We need to know every factor which determines lifespan.

Lifespan factors often but not always originate from defined genetic elements. They are not just genes, by definition they can be anything for which a Classifications schema can be build for that is related to the regulation of lifespan, such entities may include Single-Nucleotide Polymorphism, transcript variants, proteins and their complexes, compounds (i.e. small molecules like metabolites and drugs), etc. A factor should be based on a defined molecular entity or genomic position and been classified. It shall be highly flexible and scalable Concept.

While individual lifespan factors within each species or precise defined molecular entities will be captured within the Lifespan App, Data Entries of the Data App may summarize for instance the relevance of each factor class (e.g. homologous group; chemical derivate of related structure and properties, etc.) as well as draw overall conclusions. o

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  • Species: + -
    Budding yeast (1)   Nematode (7)  
  • Classifications: + -
    DR‑Essential «  No Age Effect «  Aging Associated (1)   Gerontogene (1)   Positive Gerontogene (1)   DR‑Differential (1)   DR‑Induced (4)  
  • Types: + -
    • symbol name observation species
    MXR2 peptide Methionine sulfoXide Reductase 2 Deletion or overexpression of MXR2 (alias MsrB) has no effect on replicative lifespan under normal growth conditions. Simulatonous deletion of MXR2 together with MXR1 dramatically reduces replicative lifespan by 63%. Overexpression of MXR2 under DR conditions extends replicative lifespan by 120% [15141092]. Budding yeast
    asp-3 ASpartyl Protease 3 RNA interference against asp-3 significantly reduces lifespan of eat-2(ad1116) mutants, without any significant affect on the lifespan of wild-type. Mean and 75%ile lifespan of eat-2 mutants is reduced by 13-14% and 5-9% by asp-3 RNAi. ASP-3 is upregulated in eat-2 mutants [22810224]. Nematode
    acdh-12 Acyl CoA DeHydrogenase 12 RNA interference of acdh-12 starting at hatching or only during the adulthood significantly decreases eat-2 lifespan without affecting the lifespan of wild-type [22810224]. Nematode
    pod-2 Polarity and Osmotic sensitivity Defect 2 RNA interference of pod-2 starting at hatching or only during the adulthood significantly decreases eat-2 lifespan without affecting the lifespan of wild-type. POD-2 is downregulated in eat-2 [22810224]. Nematode
    pyc-1 PYruvate Carboxylase 1 RNA interference of pyc-1 starting at hatching or only during the adulthood significantly decreases eat-2 lifespan without affecting the lifespan of wild-type. PYC-1 is downregulated in eat-2 mutants [22810224]. Nematode
    sbds-1 Shwachman-Bodian-Diamond Syndrome protein homolog 1 RNA interference of sbds-1 decreases median lifespan by 24% in daf-2 mutants [18006689]. RNAi knockdown of sbds-1 starting at hatching or only during the adulthood significantly decreases lifespan of eat-2 without affecting wild-type lifespan. SBDS-1 are elevated in eat-2 mutants. Increased content of SBDS-1 is, at least partially, required for lifespan-extension by DR [22810224]. Nematode
    unc-52 UNCoordinated 52 RNA interference of unc-52 in adulthood extends mean lifespan by 11% [17411345]. RNAi knockdown of unc-52 starting at hatching or only during the adulthood significantly decreases lifespan of eat-2 without affecting wild-type lifespan. UNC-52 levels are elevated in eat-2 mutants. Increased content of UNC-52 is, at least partially, required for lifespan-extension by DR [22810224]. Nematode
    acdh-1 Acyl CoA DeHydrogenase 1 RNAi knockdown of acdh-1 starting at hatching or only during the adulthood significantly decreases lifespan of eat-2 without affecting wild-type lifespan. ACDH-1 significantly upregulated in eat-2. Increased content of ACDH-1 is, at least partially, required for lifespan-extension by DR [22810224]. Nematode
    • 8 factors
    Factors are an extension of GenAge and GenDR.

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