Factors

We need to know every factor which determines lifespan.

Lifespan factors often but not always originate from defined genetic elements. They are not just genes, by definition they can be anything for which a Classifications schema can be build for that is related to the regulation of lifespan, such entities may include Single-Nucleotide Polymorphism, transcript variants, proteins and their complexes, compounds (i.e. small molecules like metabolites and drugs), etc. A factor should be based on a defined molecular entity or genomic position and been classified. It shall be highly flexible and scalable Concept.

While individual lifespan factors within each species or precise defined molecular entities will be captured within the Lifespan App, Data Entries of the Data App may summarize for instance the relevance of each factor class (e.g. homologous group; chemical derivate of related structure and properties, etc.) as well as draw overall conclusions. o

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  • symbol name observation species
    F18F11.1 F18F11.1 knockdown extends mean lifespan by 17% and 11%, respectively [22509016]. Nematode
    R03D7.4 RNAi against R03D7.4 increases mean and maximum lifespan by 9-17% and 7%, respectively [18059442]. Nematode
    F13G3.7 RNAi against F13G3.7 increases mean and maximum lifespan by 25% and 50%, respectively. Lifespan extension by F13G3.7 RNAi is dependent on daf-16 [12447374]. Nematode
    B0035.12 RNAi of B0035.12 increases mean and maximum lifespan by 12 and 20%, respectively [19293945]. Nematode
    E01A2.2 RNAi against E01A2.2 increases mean and maximum lifespan by 11 and 18%, respectively [19293945]. Nematode
    F13G3.10 RNAi of F13G3.10 extends mean and maximum lifespan by 11 and 14%, respectively [19293945]. Nematode
    Y56A3A.9 Y56A3A.9 RNA interference extends lifespan. Nematode
    C18E9.4 RNAi of C18E9.4 starting at L1 results in mean and median lifespan extension by about 4 and 8% [15998808]. Nematode
    F35D2.3 RNAi of F35D2.3 extends mean, 25%ile and median lifespan by 3, 8 and 8% [15998808]. Nematode
    F40F8.5 RNAi of F40F8.5 extends mean, 25%ile and median lifespan by 3, 8 and 8% [15998808]. Nematode
    T09A5.8 RNAi of cec-3 starting at L1 extends mean and 25%ile lifespan by 3 and 8% [15998808]. Nematode
    mecr-1 RNAi of mecr-1 extends mean, median and 25%ile lifespan by 6, 8 and 8% [15998808]. Nematode
    COX5 Disruption of the nuclear COX5 gene delays senescence, increase longevity between 7- and 15-fold (in 30 tested isolates) and the onset of senescence is not associated by accumulation of senescence-specific mtDNA molecules. COX5 deletion results in exclusive use of the alternative respiratory pathway and a decrease in production of reactive oxygen species and the prevention of the accumulation of several senescence-specific mitochondrial DNA molecules [10759557]. Podospora anserine
    D2030.4 RNAi against D2030.4 prolongs mean and maximum lifespan by 43% and 50%, respectively. Lifespan extension by RNAi of D2030.4 is not suppressed by daf-16. D2030.4 RNAi animals have lower ATP content and oxygen consumption [12447374]. Nematode
    F26E4.6 F26E4.6 RNA interference extends mean and maximum lifespan by about 48% and 50%, respectively. Lifespan extension by F26E4.6 RNAi is not suppressed by daf-16. F26E4.6 RNAi animals have lower ATP content and oxygen consumption [12447374]. Nematode
    F28B3.5 RNA interference of F28B3.5 extends mean lifespan by 31% and 55%, respectively, and does not cause any developmental pleiotropies nor defects in mitochondrial morphology. Lifespan extension by F28B3.5 is suppressed by daf-16. F28B3.5 animals have lower ATP content and oxygen consumption [12447374]. Nematode
    F57B10.3 RNA interference against F57B10.3 extends mean and maximum lifespan by 21% and 48%, respectively, without causing any developmental pleiotropies or defects in mitochondrial morphology. Lifespan extension by F57B10.3 is suppressed by daf-16. F57B10.3 RNAi animals have lower ATP content and oxygen consumption [12447374]. Nematode
    K01C8.7 K01C8.7 RNAi increases mean and maximum lifespan by 20% and 21%, respectively. Lifespan extension by RNAi of K01C8.7 is not suppressed by daf-16. K01C8.7 RNAi animals have lower ATP content and oxygen consumption [12447374]. Nematode
    PLD alpha Antisense suppression of PLD alpha retards abscisic acid- and ethylene-induced senescence. Leaves detached from PLD alpha-deficient transgenic plants when inbutated in abscisic acid and ethylene exhibit a slower rate of senescence that those from wild-type and transgenic controls. PLD alpha deficient strains are associated with retardation of senescence as evidenced by delayed leaf yellowing, lower ion leakage, greater photosynthetic activity, and higher content of cholorophyl and phospholipids [9437863]. Antisense suppression of PLD alpha does not affect natural plant growth and development [9437863].
    RAS1 Deletion in RAS1 increases mean (23%) and maximum (29%) replicative lifespan (in SP1) [8034612]. RAS1 deletion increases replicative lifespan by 15% in the alpha strain [19030232]. However, deletion of RAS1 slightly shortens chronological lifespan (in SP1) [12586694]. No lifespan extension results from overexpression of RAS1 (in SP1) [8034612]. Budding yeast
    phi-44 phi-44 RNAi leads to 46% mean and 50% maximum lifespan extension. Lifespan extension by phi-44 is not suppressed by daf-16. phi-44 RNAi animals have lower ATP content and oxygene consumption [12447374]. Nematode
    W09C5.8 RNAi against W09C5.8 increases mean and maximum lifespan by 62% and 50%, respectively [12447374]. Lifespan extension by RNAi of W09C5.8 is not suppressed by daf-16. Loss of W09C5.8 activity via RNAi can also result in a shortened lifespan, reduced fertility and defects in mitochondrial respiratory chain function [19074434]. W09C5.8 RNAi animals have lower ATP content and oxygen consumption [12447374]. Nematode
    YBR238C Deletion of YBR238C increases mean replicative lifespan by 25 to 34% in the alpha and a strains [16293764; 19030232]. Budding yeast
    B0511.6 RNA interference of B0511.6 in adulthood extended mean lifespan by 50% [17411345]. Nematode
    ttr-5 RNA interference of ttr-5 increase mean lifespan 14% [17608836]. Nematode
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    • 25 of 478 factors
    Factors are an extension of GenAge and GenDR.

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