| ATG18 | — | The replicative lifespan of ATG18 deletion mutant is not shorter than that of wild-type under DR [18690010]. | Budding yeast |
| git3 | — | git3 encodes a G protein-coupled receptor for glucose. git3 deletion increases chronological lifespan in conditions where glucose consumption is not affected. Constitutive activation of the G-alpha subunit acting downstream of Git3 accelerates aging and inhibits the effect of DR. The anti-aging effect of DR and git3 deletion mutation is accompanied by increased respiration and lower ROS production [19266076]. | Fission yeast |
| Vitamin C | — | Treatment with 1 mM vitamin C has no effect on lifespan of wild-type, but significantly shortens the lifespan of both isp-1 and muo-6 mutants [21151885].
Supplementation with vitamin C normalizes the median lifespan of wnr-1 and mir-124 mutants, which both exhibit premature aging [23075628]. | Nematode |
| ND2 | — | ND2 was not found to be associated with longevity [12384792]. | Human |
| MT-ND3 | — | MT-ND3 was not found to be associated with longevity [18759861]. | Human |
| APOE + TOMM40 | — | APOE + TOMM40 was not found to be associated with longevity [21418511]. APOE + TOMM40 was not found to be associated with longevity [23040522]. | Human |
| ND2 | — | ND2 was not found to be associated with longevity [12384792]. | Human |
| Downstream of LACE1 | — | Downstream of LACE1 was not found to be associated with longevity [19196970]. | Human |
| Downstream of FOXO3A | — | Downstream of FOXO3A was found to be associated with longevity [19196970]. Downstream of FOXO3A was not found to be associated with longevity [19196970]. | Human |
| IL6 + APOE | — | IL6 + APOE was not found to be associated with longevity [15236771]. | Human |
| PTK2 | — | PTK2 was found to be associated with longevity [24930376]. PTK2 was not found to be associated with longevity [24930376]. | Human |
| PVRL2 | — | PVRL2 was found to be associated with longevity [24924924]. PVRL2 was not found to be associated with longevity [24924924]. | Human |
| SOD3 | — | SOD3 was not found to be associated with longevity [24163049]. | Human |
| ATF4 | — | ATF4 was not found to be associated with longevity [23770741]. | Human |
| CBL | — | CBL was not found to be associated with longevity [23770741]. | Human |
| JUN | — | JUN was not found to be associated with longevity [23770741]. | Human |
| NOS1 | — | NOS1 was not found to be associated with longevity [23572278]. | Human |
| NOS3 | — | NOS3 was not found to be associated with longevity [23572278]. | Human |
| fem-3 | FEMinization of XX and XO animals | fem-3(e1996) mutants do not produce sperm or self-progeny, therefore develop as females, but have a normal lifespan (See also ref 10) [8247153]. | Nematode |
| TP53 | tumor protein p53 | A naturally occuring allele with decreased p53 activity has been assoicated with extended survival [15732191].TP53 was found to be associated with longevity [23125046]. TP53 was found to be associated with longevity [18256523]. TP53 was found to be associated with longevity [15621215]. TP53 was found to be associated with longevity [18256523]. TP53 was not found to be associated with longevity [15195682]. TP53 was not found to be associated with longevity [15621215]. | Human |
| — | (-)-epidcatechin | Treatment with (-)-epidcatechin do no extend C. elegans lifespan [20717869]. | Nematode |
| — | (R)-N-(2-heptyl)-N-methylpropargylamine | Addition of 0.66 ng/fly/day (R)-N-(2-heptyl)-N-methylpropargylamine to a sucrose-based diet resulted in no significant effect on lifespan, but lifespan reduction due to galactose feeding is partially suppressed by supplementation with (R)-deprnyl or (R)-N-(2-heptyl)-N-methylpropargylamine [9972869]. | Fruit fly |
| PDPK1 | 3-phosphoinositide dependent protein kinase-1 | PDPK1 was not found to be associated with longevity [19489743]. | Human |
| aak-1 | 5'-AMP-activated protein kinase catalytic subunit alpha-1 | aak-1 does not appear to be required for the control of lifespan [15574588]. | Nematode |
| tax-2 | abnormal CHEmotaxis | Loss of function mutation in tax-2 has no effect on lifespan [10617200].
tax-2 mutants are defective in chemotaxis, thermotaxis, odorant defect and have some dye-filling defects [8893026] as well as are exhibit some defects in dauer formation [10064800]. | Nematode |
