XRCC5 | X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) | XRCC5 was found to be associated with longevity [22406557; 16518718]. | Human |
XRCC4 | X-ray repair complementing defective repair in Chinese hamster cells 4 | XRCC4 was found to be associated with longevity [16518718]. | Human |
XRCC3 | X-ray repair complementing defective repair in Chinese hamster cells 3 | XRCC3 was found to be associated with longevity [16518718]. | Human |
XRCC1 | X-ray repair complementing defective repair in Chinese hamster cells 1 | XRCC1 was found to be associated with longevity [16518718]. | Human |
XDH | xanthine dehydrogenase | XDH was found to be associated with longevity [22406557; 22279548]. | Human |
TSHR | thyroid stimulating hormone receptor | Two single nucleotide in the TSHR were associated with increased TSH in both centenarians and their offspring [19837933].TSHR was found to be associated with longevity [19837933]. TSHR was not found to be associated with longevity [19837933]. | Human |
APOA4 | apolipoprotein A-IV | Two restriction polymorphisms, HinfI347 (Thr347/Ser) and Fnu4HI360 (Gln360/His), and a VNTR (alleles 3, 4) at the 3 region of the APOA4 gene were examined in 71 centenarians (18 men and 53 women, 100-107 years of age, mean 102.3 years) and 100 unrelated adults (21 men and 79 women, 19-59 years of age, mean 35.7 years). The Hinf347 genotype distribution was significantly different in centenarians [9622284].APOA4 was found to be associated with longevity [9533408]. APOA4 was found to be associated with longevity [9622284]. APOA4 was not found to be associated with longevity [9622284]. APOA4 was not found to be associated with longevity [12556235]. | Human |
SLC6A4 | solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 | Two alleles, 44-bp insertion (l allele) or deletion (s allele) in the promoter region of SLC6A4, were examined in 265 Japanese centenarians and control subjects. The frequency of the l/l genotype and the l allele was significantly greater in centenarians than in younger control subjects, particularly women [16095668].SLC6A4 was found to be associated with longevity [22985157]. | Human |
TUBB4B | tubulin, beta 2C | TUBB4B was found to be associated with longevity [22174011]. | Human |
TOMM40 | translocase of outer mitochondrial membrane 40 homolog (yeast) | TOMM440 correlates substantial with longevity and has been associated with Alzheimer's disease [22279548].
rs4420638 at TOMM40 gene locus exhibits significant association with longevity p-value = 9.6x10^-8). Combined modeling of linkage and association shows that association of longevity with APOEepsilon4 and APOEepsilon2 alleles explain the linkage at 19q1.11-q13.32 with pvalue-0.02 and p-value=1.0x10^-5, respectively [23286790]. TOMM40 was found to be associated with longevity [21418511; 23040522; 22279548]. TOMM40 was not found to be associated with longevity [24924924]. TOMM40 was found to be associated with longevity [24924924]. | Human |
XRCC6 | X-ray repair complementing defective repair in Chinese hamster cells 6 | The single-nucleotide polymorphism in rs132793 in XRCC6 has significant effect on telomere length, but it is not associated with longevity [21972126]. | Human |
ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | The R219K SNP was examined in 256 centenarians and 190 healthy younger controls. The allelic frequency were not different between the two groups [12601526]. | Human |
IL6 | interleukin 6 (interferon, beta 2) | The production of IL-6 is genetically controlled and age- and gender-dependent. IL-6 production bt aPBMC increases with age in C+ but not in C-subjects. [11772517]. | Human |
PPARG | peroxisome proliferator-activated receptor gamma | The Pro/Ala polyporphism in the PPARG gene at codon 12 was studied in 222 long-lived subjects and 250 aged subjects. A different genotype frequency was observed between long-lived and aged men; no differences were observed in the two age groups of women [15236769].PPARG was found to be associated with longevity [15236769]. PPARG was found to be associated with longevity [22985084]. | Human |
KL | klotho | The KL-VS allele of the klotho gene is more common in infants than in elderly individuals. Individuals homozygous for KL-VS have a 2.6-fold greater chance of dying by age 65 than individuals that are homozyogous that are homozyogous for the wild-type klotho allele [11792841]. KL was found to be associated with longevity [17903295; 22406557; 15677572]. KL was not found to be associated with longevity [18034366]. KL was found to be associated with longevity [24164579]. | Human |
ACE | angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 | The I/D polymorphism in ACE was a examined in centenarians (n = 338) and in adults aged 20-70 years. A variant of ACE which predisposes the coronary heat disease was more frequently in centenarians with a significant increase of the homozygous genotype [8136829].
I/D polymorphism was examined in 182 women and 100 men aged >84 years and in 100 boys and 100 girls younger than 17 years. The I/I polymorphism was depleted in the elderly males but not in the elderly females. Furthermore, significant differences were observed between ACE genotypes in elderly men and elderly women [9105559].
I/D polymorphism was examined in 394 French centenarians (13% men and 87% women) and controls (238) from 20 to 70 years of age (140 men and 98 women). Both the ACE D allele and ACE D/D genotype were more frequent in centenarians in comparison with controls, without sex-related differences nor significant correlation with a cardiovascular pathology [9761238].
I/D polymorphism was examined in 424 subjects comprising 227 Uighur individuals, 108 Kazakh individuals, and 89 Han individuals. All subjects in the latter two groups ranged in age from 65 to 70 years, whereas the Uighur subjects comprised two different age groups: those ranging in age from 59 to 70 years and those ranging in age from 90 to 113 years. Within the Uighur group, frequency of the D allele was significantly higher in the group aged >90 than in the group aged <70. The overall distributions of alleles in the three groups did not differ significantly [11773214].
Alleles of ACE was found to be associated with longevity [12547486; 22456784].ACE was found to be associated with longevity [11773214]. ACE was found to be associated with longevity [16960022]. ACE was found to be associated with longevity [19502260]. ACE was found to be associated with longevity [12634288]. ACE was found to be associated with longevity [23389097]. ACE was found to be associated with longevity [12547486]. ACE was found to be associated with longevity [22456784]. ACE was found to be associated with longevity [14528043]. ACE was found to be associated with longevity [8136829]. ACE was found to be associated with longevity [21614448]. ACE was found to be associated with longevity [21330423]. ACE was found to be associated with longevity [19502260]. ACE was found to be associated with longevity [9105559]. ACE was found to be associated with longevity [9761238]. ACE was not found to be associated with longevity [11280044]. ACE was not found to be associated with longevity [14528043]. ACE was not found to be associated with longevity [21330423]. ACE was not found to be associated with longevity [9761238]. ACE was found to be associated with longevity [23623925]. | Human |
IGF1R | insulin-like growth factor 1 receptor | The G/A, codon 1013 polymorphism was examined in healthy people 17-85 yr of age (n= 278; mean age, 54.8; 76 males and 202 females) and in healthy people 86-109 yr of age (n= 218; mean age, 98.0; 56 males and 162 females. The analysis revealed lower free IGF-I plasma levels in IGF1R A subjects (AG and AA genotypes) than in A- (GG genotype) subjects. A subjects were more represented among long-lived people than in young people [12843179].IGF1R was found to be associated with longevity [19489743]. IGF1R was found to be associated with longevity [12843179]. | Human |
HSPA1L | heat shock 70kDa protein 1-like | The frequency of the T2437C transversion (Met to Thr) polymorphism in the HSPA1L gene was investigated in a healthy aged population of 100 control samples (59% female, 41% male with an age-range of 19-45 years) and 129 aged consecutive samples (70% female, 30% male with an age range of 80-97 years). The 2437T polymorphic nucleotide was observed to increase in the elderly, although not attaining statistical significance. The TT genotype was observed to be significantly increased within the aged population, while conversely the TC genotype was significantly decreased in the aged subjects [12742533].HSPA1L was found to be associated with longevity [12742533]. HSPA1L was found to be associated with longevity [16804002]. HSPA1L was found to be associated with longevity [16804002]. | Human |
TNF | tumor necrosis factor | The frequency of the -308 polymorphism in the TNF gene was analyzed in 71 healthy elders, aged 80 to 96 years (mean 86.2 years). The control samples were obtained from 99 young (from 21 - 54 years; mean 35.2 years) healthy individuals unrelated to elders were studied, age ranged from 80 to 96 years (mean 86.2 years). The TNF2 allele was increased in the elder group when compared to young controls [16269080].TNF was found to be associated with longevity [20518833]. TNF was found to be associated with longevity [18511747]. TNF was found to be associated with longevity [12714268]. TNF was found to be associated with longevity [12714268]. TNF was found to be associated with longevity [12676903]. TNF was found to be associated with longevity [11640949]. TNF was found to be associated with longevity [21299522]. TNF was found to be associated with longevity [21299522]. TNF was not found to be associated with longevity [12676903]. TNF was found to be associated with longevity [16269080]. TNF was not found to be associated with longevity [11640949]. | Human |
PCMT1 | protein-L-isoaspartate (D-aspartate) O-methyltransferase | The distribution of genotypes in a healthy older population of Ashenazi Jewish individuals with that in a younger ethnically matched control group were compared. 65% of the healthy older population had the heterozygous genotype, greater than the 50% expected by Hardy-Weinberg equilibrium, suggesting a possible selection for having both alleles of the repair methyltransferase in successful aging [10496068].PCMT1 was found to be associated with longevity [10496068]. | Human |
IFNG | interferon, gamma | The distribution of 874T/A polymorphism in the IFNG gene was examined in 174 Italian centenarians (>99 years old, 142 women and 32 men) and 248 <60-year-old control subjects (90 women and 158 men). The +874T allele, known to be associated with low IFN-gamma production, was found less frequently in centenarian women than in centenarian men or in control women whereas no significant differences were observed in the distribution of the two alleles between male or female controls. Allele frequencies in centenarian men were not found significantly different from male controls [11772518].IFNG was found to be associated with longevity [21299522]. IFNG was not found to be associated with longevity [11772518]. IFNG was found to be associated with longevity [11772518]. | Human |
TLR4 | toll-like receptor 4 | The ASP299GLY ploymorphism in the TLR4 gene shows a significantly lower frequency in patients affected by myocardial infarction compared to controls, whereas centenarians exhibit a higher frequency [16803999]. TLR4 was found to be associated with longevity [16803999; 17493663].TLR4 was found to be associated with longevity [17493663]. TLR4 was not found to be associated with longevity [17493663]. | Human |
HSPA1B | heat shock 70kDa protein 1A | The A/G (1267 coding) polymorphism in the HSPA1B was examined in 426 participants of various ages Female carriers of GG genotype survive better than noncarriers [16804002]. | Human |
IL10 | interleukin 10 | The -1082G/A, -819C/T and -592C/A proximal promoter SNPs of the IL10 gene were examined in 190 centenarians (>99 years old, 159 women and 31 men) and in 260 control subjects (99 women and 161 men less than 60 years old). The -1082G homozygous genotype, associated with high IL-10 production, was increased in centenarian men but not in centenarian women. No difference was found between centenarians and control subjects regarding the other two SNPs [11857058].IL10 was found to be associated with longevity [20518833]. IL10 was found to be associated with longevity [12676903]. IL10 was found to be associated with longevity [12676903]. IL10 was found to be associated with longevity [11640949]. IL10 was found to be associated with longevity [21299522]. IL10 was found to be associated with longevity [21299522]. IL10 was found to be associated with longevity [11857058]. IL10 was found to be associated with longevity [15466015]. IL10 was not found to be associated with longevity [11640949]. | Human |
PDE10A | phosphodiesterase 10A | SNPs near PDE10A were associated to longevity [22773346]. | Human |