| mrpl-37 | — | Knockdown of mrpl-37 increases lifespan by 41% [23698443]. | Nematode |
| mrpl-2 | — | Knockdown of mrpl-2 increases lifespan by 54% [23698443]. | Nematode |
| mrpl-1 | — | Knockdown of mrpl-1 increases lifespan by 57% [23698443]. | Nematode |
| ttll-9 | Tubulin Tyrosine Ligase Like | Knockdown of ttll-9 throughout the entire life increases the lifespan by 3% [23698443]. | Nematode |
| nkcc-1 | Na-K-Cl Cotransporter homolog | Knockdown of nkcc-1 throughout the entire life increases the lifespan by 23% [23698443]. | Nematode |
| mrps-5 | — | Knockdown of mrps-5 throughout the entire life increases the lifespan by 60%. mrps-5 RNAi prevents aging-associated functional decline and alters mitochondrial function. Knocking down mrps-5 after early development no longer affects nematode lifespan. When RNAi of mrps-5 was performed during the larval stages only, lifespan increases by 48%, whereas RNAi started from the L4 stage has no effect. mrps-5 RNAi results in fragmented mitochondria. mrps-5 RNAi increases lifespan by 40% in widltype, 37% in daf-16(mu86), 40% in sir-2.1(ok434) 69% in aak-2(ok524) and 112% in mev-1(kn1). Knockdown of cco-1 does not extend the lifespan of mrps-5 RNAi [23698443]. | Nematode |
| frh-1 | FRataxin (involved in human Friedrich's ataxia) Homolog | Complete absence of frataxin,the mitochondrial protein defective in individuals with Friedreich ataxia is lethal, while its partial deficiency extends animal lifespan in a p53 dependent manner. Frataxin knockdown via RNAi extends mean and maximum lifespan by 19 and 37%, respectively [23247094].
Substantial reduction of frataxin protein expression is required to extend lifespan, affect sensory neurons functionality, remodel lipid metabolism and trigger autophagy. Beclin and p53 genes are required to induce autophagy and concurrently reduce lipid storages and extend animal lifespan in response to frataxin suppression. Frataxin expression modulates autophagy in the absence of p53 [23247094]. | Nematode |
| mir-239 | — | Mutating mir-239 increases mean and maximum lifespan by 12 and 36%, respectively, whereas overexpressing mir-239 decreases mean and maximum lifespan by 13 and 17 - 33%, respectively [21129974]. | Nematode |
| let-23 | LEThal 23 | Postdevelopmental inactivation of let-23 by RNA interference extends the lifespan by 5.6% [New Longevity Regulators]. | Nematode |
| cyc-2.1 | CYtochrome C 2.1 | RNA interference of cyc-2.1 increases mean lifespan by 80% [17608836]. cyc-2.1 RNAi has no significant effect on lifespan of eat-2 mutants, although CYC-2.1 levels are elevated in eat-2 mutants [22810224]. | Nematode |
| icl-1 | IsoCitrate Lyase homolog 1 | RNAi knockdown of icl-1 (alias gei-7) starting at hatching or only during the adulthood significantly extends lifespan of wild-type, but does not alter, or even shortens the lifespan of eat-2 mutants [22810224]. | Nematode |
| hpd-1 | 4-HydroxyPhenylpyruvate Dioxygenase (HPD)) 1 | RNAi knockdown of hpd-1 starting at hatching or only during the adulthood significantly extends lifespan of both wild-type and eat-2 [22810224]. | Nematode |
| fat-2 | FATty acid desaturase 2 | RNAi knockdown of fat-2 starting at hatching or only during the adulthood significantly extends lifespan of wild-type, but does not alter, or even shortens the lifespan of eat-2 mutants. FAT-2 is downregulated in eat-2 [22810224].
| Nematode |
| pyk-1 | PYruvate Kinase 1 | RNA interference of pyk-1 during adulthood significantly shortens the lifespan of both wild-type and eat-2 mutants. RNAi knockdown of pyk-1 from hatching causes larval lethality. PYK-1 is downregulated in eat-2 mutants [22810224].
pyk-1(ok1754) mutation extends the lifespan and this effect is non-additive with the lifespan extension mediated by DDS treatment [20974969]. | Nematode |
| ins-35 | INSulin related 35 | ins-35 encodes an insulin-like peptide which is downregulated in space. Mutation or RNA interference of ins-35 extends lifespan on NGM agar covered with killed or live bacteria as well as in liquid culture medium. ins-35 RNAi extends mean, 75%ile, and maximum lifespan by 8, 4, and 32%. ins-35(TM290) mutation extends mean, 75%ile, and maximum lifespan by 15-17, 14-23, and 23-24%. Lifespan extension by ins-35 mutation is totally abolished by daf-16 or skn-1 RNAi inactivation eat-2 RNAi further enhances the extension of lifespan by mutation in ins-35 [22768380].
Mutation and RNAi of ins-35 enhance pheromone-induced dauer formation [22768380].
| Nematode |
| shk-1 | SHaKer family of potassium channels 1 | shk-1 encodes a shaker family of potassium channel which functions in muscle [21059759], is expressed in sensory neurons [16899454], and downregulated in space. Mutation or RNA interference of shk-1 extends lifespan on NGM agar covered with killed or live bacteria as well as in liquid culture medium. shk-1 RNAi extends mean, 75%ile, and maximum lifespan by 16, 15, and 22%. shk-1(RB1392) mutation extends mean, 75%ile, and maximum lifespan by 19-22, 19-21, and 20-24%. Lifespan extension by unc-17 mutation is totally abolished by RNAi inactivation of either daf-16 or skn-1. eat-2 RNAi shortens the lifespan of shk-1 mutants. RNAi inactivation of shk-1 reduces Q35 aggregation [22768380].
Mutation and RNAi of shk-1 enhance pheromone-induced dauer formation [22768380].
| Nematode |
| glc-4 | Glutamate-gated ChLoride channel 4 | glc-4 encodes a glutamate-gated chloride channel which is expressed in sensory neurons [17850180] and is downregulated in space. Mutation or RNA interference of glc-4 extends lifespan on NGM agar covered with killed or live bacteria as well as in liquid culture medium. glc-4 RNAi extends the mean, 75%ile, and maximum lifespan by 13, 11, and 19%. glc-4(JD31) increases the mean, 75%ile, and maximum lifespan by 13-23, 11-23, 19-34%. Lifespan extension by glc-4 mutation is totally abolished by RNAi inactivation of either daf-16 or skn-1. eat-2 RNAi further enhances the extension of lifespan by glc-4 mutation [22768380].
Mutation and RNAi of glc-4 suppresses pheromone-induced dauer formation [22768380].
| Nematode |
| F57A8.4 | Protein F57A8.4 | F57A8.4 encodes a rhodopsin-like G-protein coupled receptor that is known to sense light [11493519] and is downregulated in space.
Mutation or RNA interference of F57A8.4 extends lifespan on NGM agar covered with killed or live bacteria as well as in liquid culture medium. F57A8.4 RNAi extends the mean, 75%ile and maximum lifespan by 34, 39, and 61%. F57A8.4(tm4341) mutation extends the mean, 75%ile, and maximum lifespan by 18-38, 21-25, and 42-68%. Lifespan extension by gar-3 mutation is not abolished by RNAi inactivation of either daf-16 nor skn-1. eat-2 RNAi shortens the lifespan of F57A8.4 mutants [22768380].
Mutation and RNAi of F57A8.4 suppresses pheromone-induced dauer formation [22768380].
| Nematode |
| cha-1 | abnormal CHoline Acetyltransferase 1 | cha-1 encodes a choline acetyltransferase which is expressed in motor [18041778] neurons and downregulated in space. Mutation or RNA interference of cha-1 extends lifespan on NGM agar covered with killed or live bacteria as well as in liquid culture medium [22768380]. cha-1(TY1652) mutation extends mean, 75%ile, and maximum lifespan by 23, 29, and 38%. The cha-1(PR1152) allele extends mean, 75%ile, and maximum lifespan by 22-49, 18-25, and 11-21%. Lifespan extension by cha-1 mutation is not abolished by daf-16 RNAi inactivation. eat-2 RNAi shortens the lifespan of cha-1 mutants. RNAi inactivation of cha-1 reduces Q35 aggregation [22768380].
cha-1 participates in determining pharyngeal pumping rate to affect food intake [6698395]. | Nematode |
| unc-17 | UNCoordinated 17 | unc-17 encodes acteylcholine transporter which is expressed in motor [18041778] and inter-neurons and is downregulated in space. Mutation of unc-17 extends lifespan on NGM agar covered with killed or live bacteria. nc-17(CB933) extends mean, 75%ile, and maximum lifespan by 31-79%, 68-89%, and 68-79%. Lifespan extension by unc-17 mutation is totally abolished by RNAi inactivation of daf-16, but not skn-1. eat-2 RNAi further enhances the extension of lifespan by mutations of unc-17 [22768380].
Mutation and RNAi of unc-17 suppresses pheromone-induced dauer formation [22768380].
| Nematode |
| gar-3 | G-protein-linked Acetylcholine Receptor 3 | gar-3 encodes a acetycholine receptor which is expressed in motor neurons and muscle [17287516], participates in acetylcholine transmission in motor neuron-muscle signalling, and is downregulated in space. Mutation or RNA interference of gar-3 extends lifespan on NGM agar covered with killed or live bacteria as well as in liquid culture medium. gar-3 RNAi extends mean, 75%ile, and maximum lifespan by 11, 14 an 17%. gar-3(VC670) mutation extends mean, 75%ile, and maximum lifespan by 5-18, 4-7 and 15-56%. Lifespan extension by gar-3 mutation is not abolished by RNAi inactivation of daf-16, skn-1, or eat-2. RNAi inactivation of gar-3 reduces Q35 aggregation [22768380]. | Nematode |
| tdp-1 | TAR DNA-binding Protein homolog 1 | tdp-1(ok803) mutation increases mean and maximum lifespan at 20 degree Celsius but not at 25 degree Celsius. tdp-1(ok803) reduce the lifespan of daf-2(e1370) mutants, but does not does not reduces the lifespan of daf-16(mu86) mutants. RNAi against tdp-1 reduces lifepsna of daf-2(e1370) mutants. tdp-1 overexpression strains have a reduced lifespan at 20 and 25 degree Celsius [Vaccaro et al. 2012]. | Nematode |
| spe-10 | defective SPErmatogenesis family member (spe-10) | Mutation of spe-10 results in a 20% increase in mean lifespan on solid media [2744235].
spe-10 mutants have a temperature sensitive defect in sperm development and their lifespan correlates with thermoterance and UV resistance [2744235]. | Nematode |
| rad-8 | RADiation sensitivity abnormal/yeast RAD-related 8 | Mutation of rad-8 increases lifespan by approximately 30% at 16 degree Celsius but not at 20 degree Celsius [8169328]
rad-8 mutants are hypersensitive to UV radiation, but not X-rays or MMS [7152245] | Nematode |
| gcy-18 | Guanylyl CYclase 18 | RNAi of gcy-18 increases mean lifespan by 25%. gcy-18 expression is repressed by daf-2 RNAi, but induced by combined RNAi of daf-16 and daf-2 [12845331]. | Nematode |
