Factors

We need to know every factor which determines lifespan.

Lifespan factors often but not always originate from defined genetic elements. They are not just genes, by definition they can be anything for which a Classifications schema can be build for that is related to the regulation of lifespan, such entities may include Single-Nucleotide Polymorphism, transcript variants, proteins and their complexes, compounds (i.e. small molecules like metabolites and drugs), etc. A factor should be based on a defined molecular entity or genomic position and been classified. It shall be highly flexible and scalable Concept.

While individual lifespan factors within each species or precise defined molecular entities will be captured within the Lifespan App, Data Entries of the Data App may summarize for instance the relevance of each factor class (e.g. homologous group; chemical derivate of related structure and properties, etc.) as well as draw overall conclusions. o

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  • Types: + -
    Gene (1)  
  • symbol name observation species
    HAC1 Homologous to Atf/Creb1 1 Deletion of HAC1 decreases mean, median and maximum replicative lifespan by 10, 8 and 5%, respectively [23167605]. Budding yeast
    OSH3 OxySterol binding protein Homolog 3 Mean replicative lifespan of OSH3 deletion mutant is not significant different from wild type. Overexpression of OSH3 with the promoter of VAC8 shortens mean replicative lifespan ad promotes vacuolar fusion [Xia et al. unpublished]. Budding yeast
    SIT4 Suppressor of Initiation of Transcription 4 SIT4 deletion slightly increases chronological lifespan and totally abolishes the lifespan shortening due to ISC1 deletion [21707788]. Budding yeast
    ATH1 Acid TreHalase Deletion of ATH1 extend the mean chronological lifespan by 17% (at 30 degree Celsus in BY4742) [22783207]. ATH1 mutants have higher trehalose levels until the end of the post-diauxic growth phase, but reaches a plateau at the level of 50-70% of wild-type in the stationary phase [22783207]. Budding yeast
    TPS3 Trehalose-6-Phosphate Synthase 3 Deletion of TPS3 extend the mean chronological lifespan by 39% (at 30 degree Celsus in BY4742) [22783207]. TPS3 mutants have higher trehalose levels until the end of the post-diauxic growth phase, but reaches a plateau at the level of 50-70% of wild-type in the stationary phase [22783207]. Budding yeast
    TSL1 Trehalose Synthase Long chain 1 Deletion of TSL1 extends the mean chronological lifespan by 43% (at 30 degree Celsus in BY4742) [22783207]. Mutant TSL1 cells have reduced oxidative carbonylation of cellular proteins throughout lifespan. TSL1 mutants have higher trehalose levels, but reaches a plateau at the level of 50-70% of wild-type in the stationary phase. TSL1 deletion cells have no altered ROS levels in pre-quiescent cells [22783207]. Budding yeast
    IRC14 Deletion of IRC14 increases mean replicative lifespan by 14-22% [16293764]. IRC14 is a dubious ORF overlapping IDH2. Budding yeast
    CPR7 Cyclosporin-sensitive Proline Rotamase 7 Deletion of CPR7 has no effect on lifespan replicative lifespan, but increases chronological lifespan [11361336] Budding yeast
    CKB2 Casein Kinase Beta' subunit Lack of Ckb2 promotes a modest but significant chronological lifespan extension and marked increase in yeat resistance [20657825]. Budding yeast
    MSN2 Multicopy suppressor of SNF1 mutation 2 Deletion of MSN2 and MSN4 extends replicative lifespan and is further extended by cyr1::mTn [14741356]. Deletion of MSN2 and MSN4 does not significantly decrease chronological lifespan under AL, but attenuates chronological lifespan extension by water starvation and 0.5% glucose restriction [18225956] as well as cancels out lifespan extension of cyr1::mTn [14741356] and decreases chronological lifespan extension of ras2 deletion mutant [12586694]. Simultaneous deletion of MSN2 and MSN4 has no effect on chronological lifespan, but prevents lifespan extension by RAS2 deletion [12586694]. msn2 msn4 has no effect on replicative lifespan in PSY316, and does not prevent lifespan extension by DR [11000115] or by high osmolarity [12391171]. Budding yeast
    MSN4 Multicopy suppressor of SNF1 mutation 4 Deletion of MSN2 and MSN4 extends replicative lifespan and is further extended by cyr1::mTn [14741356]. Deletion of MSN2 and MSN4 does not significantly decrease chronological lifespan under AL, but attenuates chronological lifespan extension by water starvation and 0.5% glucose restriction [18225956] as well as cancels out lifespan extension of cyr1::mTn [14741356] and decreases chronological lifespan extension of ras2 deletion mutant [12586694]. Simultaneous deletion of MSN2 and MSN4 has no effect on chronological lifespan, but prevents lifespan extension by RAS2 deletion [12586694]. msn2 msn4 has no effect on replicative lifespan in PSY316, and does not prevent lifespan extension by DR [11000115] or by high osmolarity [12391171]. Budding yeast
    LCB4 Long-Chain Base 4 Deletion of LCB4 increases replicative lifespan and cancels out replicative lifespan extension of 0.5% glucose DR [18690010]. Budding yeast
    HXT17 HeXose Transporter 17 HXT17 mutation extends both replicative and chronological lifespan as well as cancels out DR-induced replicative and chronological lifespan extension. Mean and maximum replicative lifespan are extended by 27 and 49%, respectively [21584246]. Budding yeast
    GUP1 Glycerol UPtake 1 GUP1 deletion extends mean and maximum replicative lifespan by 32 and 30%, respectively, as well as chronological lifespan. DR-induced maximal replicative lifespan extension is not further increased by GUP1 deletion, while gup1 mutant displayed longer chronological lifespan under DR [21584246]. Budding yeast
    AIM4 Altered Inheritance rate of Mi 4 AIM4 (alias SOY1) deletion increases chronological and replication lifespan, which is non-additive with DR. On AL mean and maximum replicative lifespan are extended by 63 and 69%, respectively. DR appears to decrease aim4-induced replication lifespan extension, indicating a negative interaction. aim4 mutation does not change DR-induced chronological lifespan extension [21584246]. Budding yeast
    HHF1 Histone H Four 1 HHF1 deletion extends mean and maximum replicative by 45 and 69%, respectively, as well as chronological lifespan. Chronological lifespan extension by HHF1 deletion and DR is non-synergistic. DR appears to extend replicative lifespan more when combined with hhf1 mutation, whereas DR does not change hhf1-induced replicative lifespan extension, suggesting a positive interaction [21584246]. Budding yeast
    FRE6 Ferric REductase 6 FRE6 deletion increases mean replicative lifespan by 14% and cancels out the lifespan extending effect of DR [22912585]. Budding yeast
    RCR2 Resistance to Congo Red 2 RCR2 deletion extends mean replicative lifespan by 18% and cancels out the lifespan extending effect of DR [22912585]. Budding yeast
    OPT2 OligoPeptide Transporter 2 OPT2 deletion increases mean and maximum replicative lifespan by 23 and 9%, respectively, and cancels out the lifespan-extending effect of DR [22912585]. Budding yeast
    ATG11 AuTophaGy related 11 ATG11 deletion extends replicative lifespan under AL and abrogates DR-lifespan extension [18690010]. Budding yeast
    COX4 Cytochrome c OXidase 4 COX4 (subunit of cytochrome oxidase) deletion decreases mitochondrial membrane potential in rho+ cells to a value intermediate between rho+ and rho0 as well as increases mean and maximum replicative lifespan by 24% and 55%, respectively. Deletion of either RTG2 or RTG3 abrogated the replicative lifespan extension by COX4 deletion. ERC levels in cox4Delta rho+ cells was the same or lower than in rho+ cells [22303396]. Budding yeast
    SLM6 Synthetic Lethal with Mss4 6 Deletion of SLM6 increases replicative lifespan by approximately 37% in BY4742 [16293764] as well as mean chronological lifespan 13 - 210% (13, 49, 52, 210) in diploid cells [21447998]. SLM6 is a dubious ORF overlapping with REI1. Budding yeast
    CTF8 Chromosome Transmission Fidelity 8 Deletion of CTF8 increases mean chronological lifespan by 15-92% (15, 18, 42, 45, 92) in diploid cells [21447998]. Budding yeast
    CCR4 Carbon Catabolite Repression 4 Deletion of CCR4 increases mean chronological lifespan by 20 - 41% (20, 33, 41) in diploid cells [21447998]. In W303R CCR4 deletion shortens replicative lifespan by approximately 80% and results in temperature sensitivity that is suppressed by SSD1-V. SSD1-V partially suppresses the short-lifespan of ccr4 mutant. CCR4 mutation is synthetically lethal in combination with deletion of MPT5 in the absence of SSD1-V [11805047]. Budding yeast
    ADE4 ADEnine requiring 4 ade4 mutation extends chronological lifespan, but not replicative lifespan, and is non-additive with 0.5% glucose or amino-acid DR on chronological lifespan extension. ADE4 deletion in atg16 mutants results only in a partial extension of the chronological lifespan by 0.5% glucose DR [20421943]. Budding yeast
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    • 25 of 128 factors
    Factors are an extension of GenAge and GenDR.

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