Factors

We need to know every factor which determines lifespan.

Lifespan factors often but not always originate from defined genetic elements. They are not just genes, by definition they can be anything for which a Classifications schema can be build for that is related to the regulation of lifespan, such entities may include Single-Nucleotide Polymorphism, transcript variants, proteins and their complexes, compounds (i.e. small molecules like metabolites and drugs), etc. A factor should be based on a defined molecular entity or genomic position and been classified. It shall be highly flexible and scalable Concept.

While individual lifespan factors within each species or precise defined molecular entities will be captured within the Lifespan App, Data Entries of the Data App may summarize for instance the relevance of each factor class (e.g. homologous group; chemical derivate of related structure and properties, etc.) as well as draw overall conclusions. o

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  • Classifications: + -
  • Types: + -
  • symbol name observation species
    alpha-LA Lipoic Acid In rats, LA confers a memory effect, by fixing the lifespan of previous feeding regimen. When animals are switched early in life (12 months) from DR to AL and supplemented with α-lipoic acid the DR typical lifespan extension is maintained, but switching early from AL supplemented with α-lipoic acid to DR blocks the lifespan extending effect [18486188]. LA exhibits the ability to compensate for age-related, long-term memory deficits in old rats [8309958] and improves the memory and learning in progeriod mice [15627516]. Culturing LA, protects neurons against death induced by hyperoxia, glutamate, iron and H2O2 [12087131; 11602326]. House mouse
    • 1 factor
    Factors are an extension of GenAge and GenDR.

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