| GHRHR | growth hormone releasing hormone receptor | GHRHR was found to be associated with longevity [22406557]. GHRHR was not found to be associated with longevity [19489743]. | Human |
| SIRT1 | sirtuin 1 | SIRT1 was found to be associated with longevity [21972126; 16257164; 16257164; 16257164; 16257164; 16257164; 21972126; 20633545]. SIRT1 was not found to be associated with longevity [16257164; 18765803].SIRT1 was found to be associated with longevity [23505545]. SIRT1 was found to be associated with longevity [23450480]. SIRT1 was not found to be associated with longevity [23450480]. | Human |
| TNF | tumor necrosis factor | The frequency of the -308 polymorphism in the TNF gene was analyzed in 71 healthy elders, aged 80 to 96 years (mean 86.2 years). The control samples were obtained from 99 young (from 21 - 54 years; mean 35.2 years) healthy individuals unrelated to elders were studied, age ranged from 80 to 96 years (mean 86.2 years). The TNF2 allele was increased in the elder group when compared to young controls [16269080].TNF was found to be associated with longevity [20518833]. TNF was found to be associated with longevity [18511747]. TNF was found to be associated with longevity [12714268]. TNF was found to be associated with longevity [12714268]. TNF was found to be associated with longevity [12676903]. TNF was found to be associated with longevity [11640949]. TNF was found to be associated with longevity [21299522]. TNF was found to be associated with longevity [21299522]. TNF was not found to be associated with longevity [12676903]. TNF was found to be associated with longevity [16269080]. TNF was not found to be associated with longevity [11640949]. | Human |
| TH | tyrosine hydroxylase | Polymorphyc repeats in intron 1 (Short and Long alleles) of the TH gene were examined in 196 centenarians (143 females and 53 males) and 358 controls (196 females and 162 male; 10-85 years old). A significant loss of LL homozygous genotypes was found at the THO locus in male but not in female centenarians with respect to matched controls [9887369].TH was found to be associated with longevity [12297342]. TH was found to be associated with longevity [21407269]. TH was found to be associated with longevity [19367319]. TH was not found to be associated with longevity [19367319]. TH was found to be associated with longevity [11053670]. TH was found to be associated with longevity [17989723]. | Human |
| PON1 | paraoxonase 1 | Polymorphism at codon 192 (Gln/Arg) of the PON1 gene was examined in 256 healthy Caucasian men (69.8 +/- 4.0 years). Gln homozygotes are more frequent in aging than Arg allele carriers [12889841].PON1 was found to be associated with longevity [15050299]. PON1 was found to be associated with longevity [15050299]. PON1 was found to be associated with longevity [17903295]. PON1 was found to be associated with longevity [12082503]. PON1 was found to be associated with longevity [12082503]. PON1 was found to be associated with longevity [12082503]. PON1 was found to be associated with longevity [16799134]. PON1 was found to be associated with longevity [16799134]. PON1 was found to be associated with longevity [15050299]. PON1 was not found to be associated with longevity [15241482]. PON1 was found to be associated with longevity [15241482]. PON1 was not found to be associated with longevity [20362697]. PON1 was not found to be associated with longevity [18034366]. | Human |
| INSR | insulin receptor | 5 intronic and 1 exonic polymorphisms in the INSR gene were examined in 122 semisupercentenarians (older than 105, 107 female, 15 male, mean age 106.8 years) and 122 healthy younger controls (105 female, 17 male, mean age 33.33). One haplotype, which was comprised of 2 intronic SNPs in linkage disequilibrium, was more frequent in semisupercentenarians than in younger controls [15582274].INSR was found to be associated with longevity [15582274]. INSR was not found to be associated with longevity [15582274]. INSR was not found to be associated with longevity [19489743]. | Human |
| IL10 | interleukin 10 | The -1082G/A, -819C/T and -592C/A proximal promoter SNPs of the IL10 gene were examined in 190 centenarians (>99 years old, 159 women and 31 men) and in 260 control subjects (99 women and 161 men less than 60 years old). The -1082G homozygous genotype, associated with high IL-10 production, was increased in centenarian men but not in centenarian women. No difference was found between centenarians and control subjects regarding the other two SNPs [11857058].IL10 was found to be associated with longevity [20518833]. IL10 was found to be associated with longevity [12676903]. IL10 was found to be associated with longevity [12676903]. IL10 was found to be associated with longevity [11640949]. IL10 was found to be associated with longevity [21299522]. IL10 was found to be associated with longevity [21299522]. IL10 was found to be associated with longevity [11857058]. IL10 was found to be associated with longevity [15466015]. IL10 was not found to be associated with longevity [11640949]. | Human |
| IGF2 | insulin-like growth factor 2 (somatomedin A) | A/G ApaI site SNP in the IGF2 gene was examined in 224 older (75 years) Jewish Jerusalem residents of Ashkenazi ethnicity (150 males and 74 females) and a group of 441 younger subjects (22 years). An increase in the A allele was observed in older Ashkenazi females and a highly significant increase was observed in the AA genotype in these subjects [15621215].IGF2 was found to be associated with longevity [19367319]. IGF2 was not found to be associated with longevity [19367319]. IGF2 was found to be associated with longevity [17989723]. IGF2 was found to be associated with longevity [15621215]. | Human |
| IFNG | interferon, gamma | The distribution of 874T/A polymorphism in the IFNG gene was examined in 174 Italian centenarians (>99 years old, 142 women and 32 men) and 248 <60-year-old control subjects (90 women and 158 men). The +874T allele, known to be associated with low IFN-gamma production, was found less frequently in centenarian women than in centenarian men or in control women whereas no significant differences were observed in the distribution of the two alleles between male or female controls. Allele frequencies in centenarian men were not found significantly different from male controls [11772518].IFNG was found to be associated with longevity [21299522]. IFNG was not found to be associated with longevity [11772518]. IFNG was found to be associated with longevity [11772518]. | Human |
| HLA-DQB1 | major histocompatibility complex, class II, DQ beta 1 | Polymorphisms in HLA class II alleles of Okinawan centenarians were analyzed. DQB105 and DQB103 alleles were significantly increased in the centenarians [9389323].HLA-DQB1 was found to be associated with longevity [9389323]. HLA-DQB1 was not found to be associated with longevity [17714903]. | Human |
| HLA-DQA1 | major histocompatibility complex, class II, DQ alpha 1 | olymorphisms in HLA class II alleles of Okinawan centenarians were analyzed. DQA10101=0104 and DQA105 alleles were significantly increased in the centenarians [9389323].HLA-DQA1 was found to be associated with longevity [9389323]. HLA-DQA1 was found to be associated with longevity [9389323]. HLA-DQA1 was not found to be associated with longevity [17714903]. | Human |
| HLA-DRB1 | major histocompatibility complex, class II, DR beta 1 | Polymorphisms in the HLA-DRB1 gene in Okinawan centenarians were analyzed. DRB1*1401 allele was significantly increased in the centenarians while DRB1*0101 and DRB1*1201 alleles were slightly decreased [9389323].HLA-DRB1 was found to be associated with longevity [9425225].HLA-DRB1 was found to be associated with longevity [9425225]. HLA-DRB1 was found to be associated with longevity [9425225]. HLA-DRB1 was found to be associated with longevity [9425225]. HLA-DRB1 was found to be associated with longevity [9389323]. HLA-DRB1 was found to be associated with longevity [12581796]. HLA-DRB1 was found to be associated with longevity [12581796]. HLA-DRB1 was found to be associated with longevity [20426625]. HLA-DRB1 was not found to be associated with longevity [16269080]. | Human |
| HFE | hemochromatosis | C282Y, H63D and S65C polymorphisms in the HFE gene were studied in 106 young controls (age range from 22 to 55 years; 40 men and 66 women) and 35 elderly subjects (age range from 91 to 105 years; seven men and 28 women). A significant difference was observed only in women in frequencies of C282Y alleles between the young and the elderly subjects. Concerning H63D polymorphisms, no significant differences were observed, between old and young people [11857056].HFE was found to be associated with longevity [11857056]. HFE was found to be associated with longevity [11857056]. HFE was found to be associated with longevity [11857056]. HFE was found to be associated with longevity [11857056]. HFE was found to be associated with longevity [11857056]. HFE was found to be associated with longevity [12714263]. HFE was not found to be associated with longevity [11857056]. HFE was not found to be associated with longevity [12714263]. | Human |
| GSTT1 | glutathione S-transferase theta 1 | Deletion in the GSTT1 was examined in 94 nonagenarians and centenarians and 418 control subjects of younger age. A significant difference in the proportion of nonagenarians and centenarians homozygotes for the deletion was observed in comparison to control subjects [11162685].GSTT1 was found to be associated with longevity [11162685]. GSTT1 was found to be associated with longevity [16574194]. GSTT1 was not found to be associated with longevity [11162685]. GSTT1 was not found to be associated with longevity [15195682]. | Human |
| APOB | apolipoprotein B (including Ag(x) antigen) | A sample of 143 centenarians and a control sample of 158 individuals were examined for polymorphism in APOB restriction fragment length (RFLP) (XbaI2488 and EcoRI4154) and variable number of tandem repeat (VNTR) (3'APOB-VNTR) polymorphisms. Neither the XbaI-RFLP nor the EcoRI-RFLP was able to discriminate between centenarians and controls, while the 3'APOB-VNTR multiallelic system revealed significant differences between the samples: the frequency of alleles with fewer than 35 repeats was lower in centenarians than in controls [9050915].apoB was found to be associated with longevity [17393087].APOB was found to be associated with longevity [15028112]. APOB was found to be associated with longevity [17393087]. APOB was not found to be associated with longevity [17393087]. APOB was found to be associated with longevity [9050915]. APOB was not found to be associated with longevity [11592926]. APOB was not found to be associated with longevity [8018664]. APOB was not found to be associated with longevity [9050915]. | Human |
| APOA4 | apolipoprotein A-IV | Two restriction polymorphisms, HinfI347 (Thr347/Ser) and Fnu4HI360 (Gln360/His), and a VNTR (alleles 3, 4) at the 3 region of the APOA4 gene were examined in 71 centenarians (18 men and 53 women, 100-107 years of age, mean 102.3 years) and 100 unrelated adults (21 men and 79 women, 19-59 years of age, mean 35.7 years). The Hinf347 genotype distribution was significantly different in centenarians [9622284].APOA4 was found to be associated with longevity [9533408]. APOA4 was found to be associated with longevity [9622284]. APOA4 was not found to be associated with longevity [9622284]. APOA4 was not found to be associated with longevity [12556235]. | Human |
| AGT | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) | M/T235 SNP in the AGT gene was examined in 187 centenarians (47 males and 140 females) and 201 controls (20-64 years) and a significant influences on survival in males were observed, with reduced hazards of death for carriers of the M235 allele [11602206].AGT was found to be associated with longevity [15621215]. AGT was found to be associated with longevity [11602206]. AGT was not found to be associated with longevity [15621215]. | Human |
| REN | renin | Polymorphic repeats in intron 7 (short and long alleles) were examined in 196 centenarians (143 females and 53 makes) and 358 controls (196 females and 162 male; 10-85 years old). No significant difference in genotype frequencies was found between centenarians and controls [9887369].REN was found to be associated with longevity [15105583]. REN was not found to be associated with longevity [9887369]. | Human |
| TLR4 | toll-like receptor 4 | The ASP299GLY ploymorphism in the TLR4 gene shows a significantly lower frequency in patients affected by myocardial infarction compared to controls, whereas centenarians exhibit a higher frequency [16803999]. TLR4 was found to be associated with longevity [16803999; 17493663].TLR4 was found to be associated with longevity [17493663]. TLR4 was not found to be associated with longevity [17493663]. | Human |
| ACE | angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 | The I/D polymorphism in ACE was a examined in centenarians (n = 338) and in adults aged 20-70 years. A variant of ACE which predisposes the coronary heat disease was more frequently in centenarians with a significant increase of the homozygous genotype [8136829].
I/D polymorphism was examined in 182 women and 100 men aged >84 years and in 100 boys and 100 girls younger than 17 years. The I/I polymorphism was depleted in the elderly males but not in the elderly females. Furthermore, significant differences were observed between ACE genotypes in elderly men and elderly women [9105559].
I/D polymorphism was examined in 394 French centenarians (13% men and 87% women) and controls (238) from 20 to 70 years of age (140 men and 98 women). Both the ACE D allele and ACE D/D genotype were more frequent in centenarians in comparison with controls, without sex-related differences nor significant correlation with a cardiovascular pathology [9761238].
I/D polymorphism was examined in 424 subjects comprising 227 Uighur individuals, 108 Kazakh individuals, and 89 Han individuals. All subjects in the latter two groups ranged in age from 65 to 70 years, whereas the Uighur subjects comprised two different age groups: those ranging in age from 59 to 70 years and those ranging in age from 90 to 113 years. Within the Uighur group, frequency of the D allele was significantly higher in the group aged >90 than in the group aged <70. The overall distributions of alleles in the three groups did not differ significantly [11773214].
Alleles of ACE was found to be associated with longevity [12547486; 22456784].ACE was found to be associated with longevity [11773214]. ACE was found to be associated with longevity [16960022]. ACE was found to be associated with longevity [19502260]. ACE was found to be associated with longevity [12634288]. ACE was found to be associated with longevity [23389097]. ACE was found to be associated with longevity [12547486]. ACE was found to be associated with longevity [22456784]. ACE was found to be associated with longevity [14528043]. ACE was found to be associated with longevity [8136829]. ACE was found to be associated with longevity [21614448]. ACE was found to be associated with longevity [21330423]. ACE was found to be associated with longevity [19502260]. ACE was found to be associated with longevity [9105559]. ACE was found to be associated with longevity [9761238]. ACE was not found to be associated with longevity [11280044]. ACE was not found to be associated with longevity [14528043]. ACE was not found to be associated with longevity [21330423]. ACE was not found to be associated with longevity [9761238]. ACE was found to be associated with longevity [23623925]. | Human |
| GHR | growth hormone receptor | Individuals with low GH/IGF-I signaling due to a defect in the growth hormone receptor (GHR) are protected against cancer. Among the human individuals with a defect in GHR no cancer deaths were observed. GHR deficiency does not appear to extend lifespan because it is associated with increased risk of heart disease [21325617]. Variants in GHR were found to be associated with longevity [19489743]. | Human |
| TSHR | thyroid stimulating hormone receptor | Two single nucleotide in the TSHR were associated with increased TSH in both centenarians and their offspring [19837933].TSHR was found to be associated with longevity [19837933]. TSHR was not found to be associated with longevity [19837933]. | Human |
| TOMM40 | translocase of outer mitochondrial membrane 40 homolog (yeast) | TOMM440 correlates substantial with longevity and has been associated with Alzheimer's disease [22279548].
rs4420638 at TOMM40 gene locus exhibits significant association with longevity p-value = 9.6x10^-8). Combined modeling of linkage and association shows that association of longevity with APOEepsilon4 and APOEepsilon2 alleles explain the linkage at 19q1.11-q13.32 with pvalue-0.02 and p-value=1.0x10^-5, respectively [23286790]. TOMM40 was found to be associated with longevity [21418511; 23040522; 22279548]. TOMM40 was not found to be associated with longevity [24924924]. TOMM40 was found to be associated with longevity [24924924]. | Human |
| KL | klotho | The KL-VS allele of the klotho gene is more common in infants than in elderly individuals. Individuals homozygous for KL-VS have a 2.6-fold greater chance of dying by age 65 than individuals that are homozyogous that are homozyogous for the wild-type klotho allele [11792841]. KL was found to be associated with longevity [17903295; 22406557; 15677572]. KL was not found to be associated with longevity [18034366]. KL was found to be associated with longevity [24164579]. | Human |
| INS | insulin | Expression of human insulin under an inducible heat shock promoter increases nematode lifespan by 25% and is also able to enhance the lifespan of daf-2 mutants [11274053]. INS was found to be associated with longevity [22406557; 19367319; 17989723; 19489743]. | Human |
