Denigma

Factors

We need to know every factor which determines lifespan.

Lifespan factors often but not always originate from defined genetic elements. They are not just genes, by definition they can be anything for which a Classifications schema can be build for that is related to the regulation of lifespan, such entities may include Single-Nucleotide Polymorphism, transcript variants, proteins and their complexes, compounds (i.e. small molecules like metabolites and drugs), etc. A factor should be based on a defined molecular entity or genomic position and been classified. It shall be highly flexible and scalable Concept.

While individual lifespan factors within each species or precise defined molecular entities will be captured within the Lifespan App, Data Entries of the Data App may summarize for instance the relevance of each factor class (e.g. homologous group; chemical derivate of related structure and properties, etc.) as well as draw overall conclusions. o

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  • Species: + -
    Nematode (6)   Fruit fly (2)  
  • Classifications: + -
    Negative Aging‑Suppressor «  Aging Differential (1)   Aging‑Suppressed (1)   Aging‑Suppressor (8)   Positive Aging‑Suppressor (3)   Gerontogene (1)   Negative Gerontogene (1)  
  • Types: + -
    miRNA «  Gene (8)  
    • symbol name observation species
    mir-277 — Constitutive miR-277 expression shortens lifespan and synthetically lethal with reduced insulin signaling, indicating that metabolic control underlies this phenotype. Transgenic inhibition with a miRNA sponge construct also shortens lifespan [23669073]. miR-277 is downregulated during adult life [23669073]. mir-277 controls branched-chain amino acid catabolism and as a result it can modulate the activity of TOR kinase [23669073]. Fruit fly
    mir-124 — Loss of mir-124 increases reactive oxygen species formation and accumulation of the aging marker lipofuscin, reduces whole body ATP levels and results in reduction in lifespan [23075628]. Supplementation of vitamin C normalizes the reduced median lifespan of mir-124 mutants [23075628]. The expression of the conserved mir-124 in whole wrn-1 mutants (which premature age) is significantly reduced [23075628]. Nematode
    mir-58 — mir-58(n4640) mutation decreases the mean lifespan by 20% [22482727]. Nematode
    mir-14 mir-14 stem loop Mutating mir-14 decreases lifespan in both sexes. mir-14 reduces the mean and maximum lifespan of females by 55 and 36%, respectively, while those of males is reduced by 29 and 21%, respectively [12725740]. Fruit fly
    mir-246 — Mutating mir-246 decreases mean and maximum lifespan by 12%, while its overexpression increases mean and maximum lifespan by 6 and 5 - 14%, respectively [21129974]. Nematode
    mir-238 — Mutating mir-238 decreases mean and maximum lifespan by 18 and 24% [21129974]. mir-238(n4112) mutation decreases mean lifespan by 20% [22482727]. Nematode
    mir-71 — Loss and gain-of-function of mir-71 decreases and increases lifespan, respectively [21129974]. mir-71 mutants have a reduced lifespan with 40% decrease in mean lifespan, while extra copies of mir-71 extend the lifespan with an increase in lifespan by 15 - 25% [22482727], Loss of mir-71 function suppresses the long lifespan of glp-1(e2141) mutants [22482727], During adulthood mir-71 is strongly expressed in the intestine, body wall muscles and neurons. mir-71 is upregulated in aging adults [22482727], Nematode
    lin-4 abnormal cell LINeage 4 A loss-of-function mutation in lin-4 shortens lifespan and accelerated tissue ageing while overexpressing lin-4 extends lifespan by redarding aging [16373574]. lin-4 is regulated by DAF-16 in L1 arrest. Nematode
    • 8 factors
    Factors are an extension of GenAge and GenDR.

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