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Symbol: egl-15 Name: EGg Laying defective Alias: EGg Laying defective family member (egl-15);WBGENE00001184 Entrez gene ID: 181291 Ensembl gene ID: F58A3.2 Species: Worm (Taxid: 6239) Functional description: Activation leads to the phosphorylation of SOC-1 on Tyr- 408 triggering PTP-2 recruitment and/or activation. Activates the SEM-5/SOS-1/RAS/MAPK pathway. Acts in the hypodermis to regulate axon growth. Isoform 2 has no effect on axon growth but affects the maintenance of axon position. Isoform b acts as a receptor for an extracellular signal required for the guidance of sex myoblast migration during gonad development. Isoforms 1, 3, 4 and 5 appear to play a role in maintaining body morphology at higher temperatures. [UniProt] Observation: egl-15 RNAi in the adulthood extends the lifespan [New longevity regulators]. Interventions: Assays: Organismal Lifespan Classification: Aging Relevance Analysis/Source:  GenAge GenDRHomologs Edit \ Update (Admin) | Delete |
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