Denigma: Factor

Wrn

Symbol: Wrn
Entrez gene ID: 22427
Ensembl gene ID: ENSMUSG00000031583
Species: Mouse (Taxid: 10090)

Function:
DNA helicase/exonuclease

Observation:

Mice lacking the helicase domain of the WRN ortholog exhibit many phenotypic features of Werner Syndrom, including a pro-oxidant status and a shorter mean lifespan. Mice with a deletion in the helicase domain [9789047] recapitulates most of the Werner syndrome phenotypes, including an abnormal hyaluronic acid excretion, higher reactive oxygen species levels, dyslipidemia, increased genomic instability, and cancer incidence. Wrn(Dehl/Dehl) mutant mice have a 10 - 15% decrease in their mean lifespan [12707040; 19741171].

Interventions:

Wrn mutation -10 to -15%

Assays: Organismal Lifespan
Mean: -10 to -15

Classification:

Aging-Suppressor

Negative Aging-Suppressor

References:

12707040: Genetic cooperation between the Werner syndrome protein and poly(ADP-ribose) polymerase-1 in preventing chromatid breaks, complex chromosomal rearrangements, and cancer in mice.

19741171: Vitamin C restores healthy aging in a mouse model for Werner syndrome.

Aging Relevance Analysis/Source:

GenAge