Denigma

TSHR

Symbol: TSHR
Name: thyroid stimulating hormone receptor
Entrez gene ID: 7253
Ensembl gene ID: ENSG00000165409
Species: Human (Taxid: 9606)

Function:
Endocrine control; Binds TSH to stimulate T4 production and secretion

Observation:

Two single nucleotide in the TSHR were associated with increased TSH in both centenarians and their offspring [19837933].TSHR was found to be associated with longevity [19837933]. TSHR was not found to be associated with longevity [19837933].



Assays: Organismal Lifespan

Longevity Associated Variants:
  • rs12050077 0.01 [19837933]
  • rs10149689 0.08 [19837933]

    • Classification:
  • Aging Associated
  • Longevity-Associated
  • No Age Effect


    • Type:
  • Gene
  • Protein coding

    References:
  • 19837933: Genetic predisposition to elevated serum thyrotropin is associated with exceptional longevity.


    • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

    • Homologs
  • TSHR (9606)
  • TSHR (9598)
  • TSHR (9615)
  • TSHR (9913)
  • Tshr (10090)
  • Tshr (10116)
  • TSHR (9031)
  • LOC560609 (7955)

    • Inparanoids
  • ENSMUSP00000021346 (10090)
  • ENSRNOP00000005671 (10116)
  • ENSMMUP00000025913 (9544)



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