IGF1R

Symbol: IGF1R
Name: insulin-like growth factor 1 receptor
Entrez gene ID: 3480
Ensembl gene ID: ENSG00000140443
Species: Human (Taxid: 9606)


Observation:

The G/A, codon 1013 polymorphism was examined in healthy people 17-85 yr of age (n= 278; mean age, 54.8; 76 males and 202 females) and in healthy people 86-109 yr of age (n= 218; mean age, 98.0; 56 males and 162 females. The analysis revealed lower free IGF-I plasma levels in IGF1R A subjects (AG and AA genotypes) than in A- (GG genotype) subjects. A subjects were more represented among long-lived people than in young people [12843179].IGF1R was found to be associated with longevity [19489743]. IGF1R was found to be associated with longevity [12843179].



Assays: Organismal Lifespan

Longevity Associated Variants:
  • rs2272037 0.021 [19489743]
  • rs2229765 0.03 [12843179]

  • Classification:
  • Longevity-Associated


  • Type:
  • Gene
  • Protein coding

    References:
  • 12843179: Polymorphic variants of insulin-like growth factor I (IGF-I) receptor and phosphoinositide 3-kinase genes affect IGF-I plasma levels and human longevity: cues for an evolutionarily conserved mechanism of life span control.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • IGF1R (9606)
  • IGF1R (9598)
  • IGF1R (9615)
  • IGF1R (9913)
  • Igf1r (10090)
  • Igf1r (10116)
  • IGF1R (9031)
  • igf1ra (7955)
  • igf1rb (7955)
  • InR (7227)
  • INR (7165)
  • daf-2 (6239)

  • Orthologs
  • daf-2 (6239)
  • daf-2 (6239)

  • Inparanoids
  • ENSP00000268035 (9606)
  • ENSMUSP00000005671 (10090)
  • ENSRNOP00000019267 (10116)
  • ENSMMUP00000016141 (9544)
  • ENSP00000268035 (9606)



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