IGF1

Symbol: IGF1
Name: insulin-like growth factor 1 (somatomedin C)
Entrez gene ID: 3479
Ensembl gene ID: ENSG00000017427
Species: Human (Taxid: 9606)

Functional description:
The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. [UniProt]

Observation:

Males exhibit an age-related increase in the A-allele of rs2229765 and a change in the plasma level of IGF-1, which dropped significantly after 85 years of age. In males +over 85 years, A/A homozygous individuals have the lowest plasma IGF-1 level. However, ther was no clear correlation between rs2229765 genotype and IGF-1 in females [19460140].IGF1 was found to be associated with longevity [20199671]. IGF1 was found to be associated with longevity [18761080]. IGF1 was found to be associated with longevity [18761080]. IGF1 was found to be associated with longevity [18761080]. IGF1 was not found to be associated with longevity [19489743].



Assays: Organismal Lifespan

Longevity Associated Variants:
  • microsatellite polymorphism surrounded by rs2288377, rs5742612, and rs35767 0.922 [20199671]
  • rs2288377 1.0 [18761080]
  • rs5742612 1.0 [18761080]
  • rs35767 1.0 [18761080]
  • - None [22113349]
  • 6 SNPs, not specified None [19489743]

  • Classification:
  • Longevity-Associated
  • No Age Effect


  • References:
  • 19460140: A polymorphic variant of the insulin-like growth factor 1 (IGF-1) receptor correlates with male longevity in the Italian population: a genetic study and evaluation of circulating IGF-1 from the "Treviso Longeva (TRELONG)" study.


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • IGF1 (9606)
  • IGF1 (9598)
  • IGF1 (9615)
  • IGF1 (9913)
  • Igf1 (10090)
  • Igf1 (10116)
  • IGF1 (9031)
  • igf1 (7955)

  • Inparanoids
  • ENSMUSP00000056668 (10090)
  • ENSRNOP00000005949 (10116)
  • ENSMMUP00000002988 (9544)



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