CKA2

Symbol: CKA2
Name: CK2 subunit 2
Alias: YOR29-12
Entrez gene ID: 854227
Ensembl gene ID: YOR061W
Species: Yeast (Taxid: 4932)

Functional description:
Cka2p; Alpha' catalytic subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerase [Source:SGD;Acc:S000005587] [Ensembl]

Observation:

CKA2 deletion approximately doubles mean chronological lifespan under starvation/extreme DR in BY4741 also increases as well as as heat-shock resistance in SDC medium in the W303-1A and DBY746 genetic backgrounds [20657825].



Interventions:
  • CKA2 deletion

  • Assays: Chronological Lifespan

    Classification:
  • Gerontogene
  • Positive Gerontogene


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • CSNK2A1 (9606)
  • CSNK2A1 (9615)
  • CSNK2A1 (9913)
  • Csnk2a1 (10090)
  • Gm10031 (10090)
  • Csnk2a1 (10116)
  • CSNK2A1 (9031)
  • zgc:86598 (7955)
  • ck2a1 (7955)
  • CkIIalpha (7227)
  • AgaP_AGAP005569 (7165)
  • kin-3 (6239)
  • cka1 (4896)
  • CKA2 (4932)
  • KLLA0F16467g (28985)
  • AGOS_ADR204W (33169)
  • GeneID:2676973 (148305)
  • NCU03124 (5141)
  • CKA1 (3702)
  • CKA2 (3702)
  • Os07g0114400 (4530)
  • CK2alpha (5833)



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