CCS1

Symbol: CCS1
Name: Copper Chaperone for SOD1 1
Entrez gene ID: 855054
Ensembl gene ID: YMR038C
Species: Yeast (Taxid: 4932)

Functional description:
Ccs1p; Copper chaperone for superoxide dismutase Sod1p, involved in oxidative stress protection; Met-X-Cys-X2-Cys motif within the N-terminal portion is involved in insertion of copper into Sod1p under conditions of copper deprivation [Source:SGD;Acc:S000004641] [Ensembl]

Observation:

Deletion of CCS1 reduces replicative lifespan by 50% [17460215].



Interventions:
  • CCS1 deletion -50%

  • Assays: Replicative Lifespan

    Classification:
  • Aging-Suppressor
  • Negative Aging-Suppressor


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • CCS1 (4932)
  • KLLA0F26917g (28985)
  • GeneID:2675340 (148305)
  • NCU07851 (5141)



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