LAG1

Symbol: LAG1
Name: Ceramide synthase component
Entrez gene ID: 856386
Ensembl gene ID: YHL003C
Species: Yeast (Taxid: 4932)

Functional description:
Lag1p; Ceramide synthase component, involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lac1p [Source:SGD;Acc:S000000995] [Ensembl]

Observation:

A gene deletion of LAG1 in haploid cells results in a pronounced increase (approximately 50%) in mean and in maximum replicative lifespan in the YPHDF-1A strain [8195187], but has no significant effect on lifespan in stains W303R or PSY316 (N. Bishop, G.Liszt, and L. Guarente, unpublished]. The LAG1 transcribed is preferentially expressed in young cells. LAG1 null mutant is viable and has no obvious phenotypes but shows delayed ER to Golgi transport when combined with DGT1 mutation [10198056] and is synthetical lethal with LAC1 deletion.



Interventions:
  • LAG1 deletion +50% +50%

  • Assays: Replicative Lifespan

    Classification:
  • Gerontogene
  • Positive Gerontogene


  • Aging Relevance Analysis/Source:
  • GenAge
  • GenDR

  • Homologs
  • lac1 (4896)
  • LAG1 (4932)
  • LAC1 (4932)
  • KLLA0B13497g (28985)
  • AGOS_ABR009W (33169)
  • GeneID:2675700 (148305)
  • NCU00008 (5141)

  • Note: Has no significant effect in other strains.

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